Protein-based conjugates are valuable constructs for a variety of applications. Conjugation
of proteins to fluorophores is commonly used to study their cellular localization and the …

Nonribosomal peptide synthetases (NRPSs) are very large proteins that produce small
peptide molecules with wide-ranging biological activities, including environmentally friendly …

Enzymatic processes have always played an important role for mankind. The application of
baker's yeast for brewery, for example, is a technique with a large impact on human culture …

Nonribosomal peptide synthetases (NRPSs) are large modular enzymes that synthesize
secondary metabolites and natural product therapeutics. Most NRPS biosynthetic pathways …

To meet recent advancements in the covalent reporter labeling of proteins, we propose a
flexible synthesis for reporter analogs. Here we demonstrate a one-pot chemo-enzymatic …

Nonribosomal peptide synthetases (NRPSs) are mega-enzymes responsible for the
biosynthesis of many clinically important natural products, from early modern medicines …

Engineered biosynthetic assembly lines could revolutionize the sustainable production of
bioactive natural product analogs. Although yeast display is a proven, powerful tool for …

Co enzyme A (CoA) is a ubiquitous cofactor present in every known organism. The
thioesters of CoA are core intermediates in many metabolic processes, such as the citric …

Phosphorus (P) compounds play a crucial role in modern society; fertilisers, pesticides and
herbicides that maintain global crop outputs and many life-saving pharmaceuticals all …

Three central steps during the biosynthesis of cytochalasan precursors, including reductive
release, Knoevenagel cyclisation and Diels Alder cyclisation are not yet understood at a …