Discoveries have emerged highlighting the complex nature of the interorgan cross-talk
between the kidney and the lung. Vascular rigidity, neurohormonal activation, tissue …

ARDS is associated with poor clinical outcomes, with a pooled mortality rate of
approximately 40% despite best standards of care. Current therapeutic strategies are based …

Background In patients with the acute respiratory distress syndrome, massive alveolar
collapse and cyclic lung reopening and overdistention during mechanical ventilation may …

Background In patients with acute lung injury (ALI) and acute respiratory distress syndrome
(ARDS), mortality remains high. These patients require mechanical ventilation, which has …

Lactic acidosis is frequently encountered in the intensive care unit. It occurs when there is an
imbalance between production and clearance of lactate. Although lactic acidosis is often …

Both reduction in tidal volume (Vt) and alveolar recruitment may be important to limit
ventilator-associated lung injury during mechanical ventilation of patients with the acute …

A 55-year-old man is hospitalized with severe community-acquired pneumonia, and the
acute respiratory distress syndrome (ARDS) develops. The patient requires intubation and …

Purpose To evaluate the effects of acute hypercapnia induced by positive end-expiratory
pressure (PEEP) variations at constant plateau pressure (P plat) in patients with severe …

Objective: Pulmonary hypertension may be encountered in the intensive care unit in patients
with critical illnesses such as acute respiratory distress syndrome, left ventricular …

Objective: The hemodynamic impact of positive end-expiratory pressure in acute respiratory
distress syndrome and the underlying mechanisms have not been extensively investigated …