The development and application of emerging technologies of Industry 4.0 enable the
realization of digital twins (DT), which facilitates the transformation of the manufacturing …

In this age of technology, the vision of manufacturing industries built of smart factories is not
a farfetched future. As a prerequisite for Industry 4.0, industrial sectors are moving towards …

The manufacturing of recombinant protein is traditionally divided in two main steps:
upstream (cell culture and synthesis of the target protein) and downstream (purification and …

Abstract Adoption of Quality by Design (QbD) principles, regulatory support of QbD, process
analytical technology (PAT), and continuous manufacturing are major factors effecting new …

Biopharmaceuticals have revolutionized the field of medicine in the types of active
ingredient molecules and treatable indications. Adoption of Quality by Design and Process …

Real‐time monitoring of bioprocesses by the integration of analytics at critical unit
operations is one of the paramount necessities for quality by design manufacturing and real …

Clean meat (meat grown in cell culture rather than obtained from animal slaughter) is an
emerging biotechnology industry that will ameliorate the serious environmental …

The production of active pharmaceutical ingredients (APIs) is currently undergoing its
biggest transformation in a century. The changes are based on the rapid and dramatic …

Great importance is being given to the impact our food supply chain and consumers' food
habits are having on the environment, human health, and animal welfare. One of the latest …

The industrial production of complex biopharmaceuticals using recombinant mammalian cell
lines is still mainly built on a quality by testing approach, which is represented by fixed …