Abstract DNMT1 (DNA methyltransferase 1) is the predominant member of the DNMT family
and the most abundant DNMT in various cell types. It functions as a maintenance DNMT and …

DNA methylation is considered an essential epigenetic event during leukaemogenesis and
the emergence of drug resistance, which is primarily regulated by DNA methyltransferases …

Pan-histone deacetylase (HDAC) inhibitors often have some toxic side effects. In this study,
three series of novel polysubstituted N-alkyl acridone analogous were designed and …

The influence of metal elements on the biomedical activity of microalgal exopolysaccharides
(EPS) remains underexplored. This study examined the antitumor properties of …

The objective of this review was to explore the trends and chemical characteristics of
acridines and their derivatives, analyze their contribution to the scientific literature and …

Acute myeloid leukemia (AML) is a life-threatening aggressive malignancy of the bone
marrow and has posed a great challenge to the clinic, due to a lack of fully understanding of …

Colorectal cancer remains a significant cause of mortality worldwide. A spiro-acridine
derivative,(E)-1′-((4-bromobenzylidene) amino)-5′-oxo-1′, 5′-dihydro-10H-spiro …

Abstract 3D bioprinting is a promising technology which typically uses bioinks to pattern
cells and their scaffolds. The selection of cytocompatible inks is critical for the printing …

Cerebral infarction is the main cause of death and long-term disability worldwide. Neuronal
degeneration and limp sensory dysfunction are the secondary damages induced by cerebral …