High-throughput screening of natural product and synthetic molecule libraries for antibacterial drug discovery

NJ Ayon - Metabolites, 2023 - mdpi.com
Due to the continued emergence of resistance and a lack of new and promising antibiotics,
bacterial infection has become a major public threat. High-throughput screening (HTS) …

[HTML][HTML] A review for cell-based screening methods in drug discovery

F Wei, S Wang, X Gou - Biophysics Reports, 2021 - ncbi.nlm.nih.gov
With the biological relevance of the whole cells, low cost compared with animal experiments,
a wide variety of cell-based screening platforms (cell-based assay, cell-based microfluidics …

Naturally occurring osteoarthritis features and treatments: Systematic review on the aged guinea pig model

F Veronesi, F Salamanna, L Martini, M Fini - International Journal of …, 2022 - mdpi.com
To date, several in vivo models have been used to reproduce the onset and monitor the
progression of osteoarthritis (OA), and guinea pigs represent a standard model for studying …

Biopatterning of 3D cellular model by contactless magnetic manipulation for cardiotoxicity screening

R Onbas, A Arslan Yildiz - Tissue Engineering Part A, 2024 - liebertpub.com
Impact statement Contactless manipulation and cell patterning techniques provide rapid and
cost-effective three-dimensional (3D) cell culture model formation for tissue engineering …

Cartilaginous organoids: advances, applications, and perspectives

Y Yu, J Wang, Y Li, Y Chen… - Advanced NanoBiomed …, 2023 - Wiley Online Library
Cartilage is a nonvascular and non‐neural, mesoderm‐derived tissue. Cartilage repair,
especially articular cartilage repair and reconstruction, has always been a difficult problem …

Corneal fibrosis: From in vitro models to current and upcoming drug and gene medicines

LT Cubillo, M Gurdal, DI Zeugolis - Advanced Drug Delivery Reviews, 2024 - Elsevier
Fibrotic diseases are characterised by myofibroblast differentiation, uncontrolled
pathological extracellular matrix accumulation, tissue contraction, scar formation and …

Enhanced chondrogenic potential in GelMA-based 3D cartilage model via Wnt3a surface immobilization

A Imere, NC Foster, H Hajiali, KE Okur, AL Wright… - Scientific Reports, 2024 - nature.com
Cartilage tissue engineering aims to develop functional substitutes for treating cartilage
defects and osteoarthritis. Traditional two-dimensional (2D) cell culture systems lack the …

Features and methods of making nanofibers by electrospinning, phase separation and self-assembly

F Bafande, M Sheikh Arabi - Jorjani Biomedicine Journal, 2022 - goums.ac.ir
One of the major challenges in the field of tissue engineering is the production of scaffolding
in nano-scale. The study of structural-functional connections in pathological and normal …

Biological Scaffolds in 3D Cell Models: Driving Innovation in Drug Discovery

R Dave, K Pandey, R Patel, N Gour… - Stem Cell Reviews and …, 2024 - Springer
The discipline of 3D cell modeling is currently undergoing a surge of captivating
developments that are enhancing the realism and utility of tissue simulations. Using bioinks …

Sericin nano-gel agglomerates mimicking the pericellular matrix induce the condensation of mesenchymal stem cells and trigger cartilage micro-tissue formation …

Q Zhang, W Zhou, F Yang, J Shi - Biomaterials Science, 2023 - pubs.rsc.org
Mesenchymal stem cells (MSCs) are excellent seed cells for cartilage tissue engineering
and regenerative medicine. Though the condensation of MSCs is the first step of their …