Glioblastoma (GBM) is an aggressive nervous system tumor with a poor prognosis.
Although, surgery, radiation therapy, and chemotherapy are the current standard protocol for …

A major malignant trait of gliomas is their remarkable infiltration capacity. When glioma
develops, the tumor cells have already reached the distant part. Therefore, complete …

Rationale: Glioma stem-like cells (GSCs) contribute to temozolomide (TMZ) resistance in
gliomas, although the mechanisms have not been delineated. Methods: In vitro functional …

Here, we provide the first evidence that sphingosine kinase 1 (SphK1), an oncogenic lipid
kinase balancing the intracellular level of key signaling sphingolipids, modulates the …

RhoB is a Rho family GTPase that is highly similar to RhoA and RhoC, yet has distinct
functions in cells. Its unique C-terminal region is subject to specific post-translational …

Therapies targeting glioma cells that diffusely infiltrate normal brain are highly sought after.
Our aim was to identify novel approaches to this problem using glioma spheroid migration …

Integrins are extracellular matrix receptors involved in tumour invasion and angiogenesis.
Although there is evidence that inhibiting integrins might enhance the efficiency of …

The presence of hypoxic areas in glioblastoma is an important determinant in tumor
response to therapy and, in particular, to radiotherapy. Here we have explored the …

Background/Aims: Anaplastic thyroid carcinoma (ATC) is one of the most lethal human
malignancies, and there is no efficient method to slow its process. Apatinib, a novel tyrosine …

Rationale: RhoA and Rho kinase contribute to pulmonary vasoconstriction and vascular
remodeling in pulmonary hypertension. RhoB, a protein homologous to RhoA and activated …