Opportunities and challenges for co-delivery nanomedicines based on combination of phytochemicals with chemotherapeutic drugs in cancer treatment

Q Gao, J Feng, W Liu, C Wen, Y Wu, Q Liao… - Advanced drug delivery …, 2022 - Elsevier
The therapeutic limitations such as insufficient efficacy, drug resistance, metastasis, and
undesirable side effects are frequently caused by the long duration monotherapy based on …

Revisiting luteolin: An updated review on its anticancer potential

A Rauf, P Wilairatana, PB Joshi, Z Ahmad, A Olatunde… - Heliyon, 2024 - cell.com
Numerous natural products found in our diet, such as polyphenols and flavonoids, can
prevent the progression of cancer. Luteolin, a natural flavone, present in significant amounts …

D-mannose functionalized MgAl-LDH/Fe-MOF nanocomposite as a new intelligent nanoplatform for MTX and DOX co-drug delivery

M Pooresmaeil, H Namazi - International Journal of Pharmaceutics, 2022 - Elsevier
Commonly the directly administered chemotherapy drugs lack targeting in tumor treatment.
Thus, trying to improve cancer treatment efficiency led us to design a new intelligent system …

Apigeninidin-rich Sorghum bicolor (L. Moench) extracts suppress A549 cells proliferation and ameliorate toxicity of aflatoxin B1-mediated liver and kidney …

SE Owumi, AI Kazeem, B Wu, LO Ishokare… - Scientific reports, 2022 - nature.com
Sorghum bicolor plant has a high abundance of 3-deoxyanthocyanins, flavonoids and other
polyphenol compounds that have been shown to offer numerous health benefits …

[HTML][HTML] Molecular design, synthesis and anticancer activity of new thiopyrano [2, 3-d] thiazoles based on 5-hydroxy-1, 4-naphthoquinone (juglone)

I Ivasechko, A Lozynskyi, J Senkiv… - European journal of …, 2023 - Elsevier
Abstract A series of 11-substituted 9-hydroxy-3, 5, 10, 11-tetrahydro-2H-benzo [6, 7]
thiochromeno [2, 3-d][1, 3] thiazole-2, 5, 10-triones 3.1–3.13 were synthesized via hetero …

Caffeic acid mitigates aflatoxin B1‐mediated toxicity in the male rat reproductive system by modulating inflammatory and apoptotic responses, testicular function, and …

SE Owumi, CE Irozuru, UO Arunsi… - Journal of food …, 2022 - Wiley Online Library
Abstract Aflatoxin B1 (AFB1) is a toxic metabolite of public health concern. The present study
investigates the protective effects of caffeic acid (CA) against AFB1‐induced oxidative stress …

Quercetin alleviates the immunotoxic impact mediated by oxidative stress and inflammation induced by doxorubicin exposure in rats

MR Farag, AAA Moselhy, A El-Mleeh, SH Aljuaydi… - Antioxidants, 2021 - mdpi.com
Doxorubicin (DOX) is a chemotherapeutic agent against hematogenous and solid tumors
with undesirable side effects including immunosuppression. Quercetin (QUR), a natural …

Protective effect of luteolin against chemical and natural toxicants by targeting NF‐κB pathway

S Mahdiani, N Omidkhoda, S Heidari, AW Hayes… - Biofactors, 2022 - Wiley Online Library
Humans are continuously exposed to environmental, occupational, consumer and
household products, food, and pharmaceutical substances. Luteolin, a flavone from the …

A review of the effects of olive oil-cooking on phenolic compounds

R Ambra, S Lucchetti, G Pastore - Molecules, 2022 - mdpi.com
The fate of phenolic compounds in oil and food during cooking vary according to the type of
cooking. From a nutritional point of view, reviews largely suggest a preference for using …

3-Indolepropionic acid upturned male reproductive function by reducing oxido-inflammatory responses and apoptosis along the hypothalamic-pituitary-gonadal axis of …

SE Owumi, MT Otunla, UO Arunsi, ES Najophe - Toxicology, 2021 - Elsevier
We examined the effect of 3-Indolepropionic acid (3-IPA), an antioxidant on the
organophosphorus pesticide chlorpyrifos (CPF)-induced reproductive toxicity in rats. The …