[HTML][HTML] Review of anticancer potentials and structure-activity relationships (SAR) of rhodanine derivatives

LJ Yin, AKD bin Ahmad Kamar, GT Fung… - Biomedicine & …, 2022 - Elsevier
Rhodanine has been recognized as a privileged scaffold in medicinal chemistry due to its
well-known ability to demonstrate a broad range of biological activities. The possibility of …

[HTML][HTML] Rhodanine scaffold: A review of antidiabetic potential and structure–activity relationships (SAR)

AKD bin Ahmad Kamar, LJ Yin, CT Liang… - Medicine in Drug …, 2022 - Elsevier
Diabetes is a chronic medical condition due to the lack of insulin or ineffective use of insulin.
In recent years, diabetes has become one of the rapidly growing chronic diseases, and it …

[HTML][HTML] Novel hybrid pyrrolidinedione-thiazolidinones as potential anticancer agents: Synthesis and biological evaluation

N Finiuk, A Kryshchyshyn-Dylevych, S Holota… - European journal of …, 2022 - Elsevier
A series of novel pyrrolidinedione-thiazolidinones was synthesized and subjected to physico-
chemical characteristics. They were screened on a panel of cell lines representing different …

Anticancer profile of rhodanines: Structure–activity relationship (SAR) and molecular targets—A review

J Szczepański, H Tuszewska, N Trotsko - Molecules, 2022 - mdpi.com
The rhodanine core is a well-known privileged heterocycle in medicinal chemistry. The
rhodanines, as subtypes of thiazolidin-4-ones, show a broad spectrum of biological activity …

Synthesis and anticancer activity of novel quinazolinone-based rhodanines

S El-Sayed, K Metwally, AA El-Shanawani… - Chemistry central …, 2017 - Springer
Background Rhodanines and quinazolinones have been reported to possess various
pharmacological activities. Results A novel series of twenty quinazolinone-based …

Synthesis and anticancer activity evaluation of 5-[2-chloro-3-(4-nitrophenyl)-2-propenylidene]-4-thiazolidinones

K Buzun, A Kryshchyshyn-Dylevych, J Senkiv… - Molecules, 2021 - mdpi.com
A series of novel 5-[(Z, 2 Z)-2-chloro-3-(4-nitrophenyl)-2-propenylidene]-thiazolidinones
(Ciminalum–thiazolidinone hybrid molecules) have been synthesized. Anticancer activity …

The importance of rhodanine scaffold in medicinal chemistry: A comprehensive overview

A Mermer - Mini Reviews in Medicinal Chemistry, 2021 - ingentaconnect.com
After the clinical use of epalrestat that contains a rhodanine ring, in type II diabetes mellitus
and diabetic complications, rhodanin-based compounds have become an important class of …

Green hemi-synthesis of novel thiazole derivatives from Ammodaucus leucotrichus Coss. & Dur. and Cuminum cyminum L. essential oils: stereochemistry, molecular …

R Hassaine, IA El Haci, A Bouchama… - Journal of Molecular …, 2022 - Elsevier
This paper reports the hemi-synthesis of a new thiazole derivatives from 3-allylrhodanine
under green chemical conditions (solvent free and ambient temperature). Two targeted …

Polyrhodanine-based nanomaterials for biomedical applications: A review

IH Hiba, JK Koh, CW Lai, SM Mousavi, IA Badruddin… - Heliyon, 2024 - cell.com
Rhodanine is a heterocyclic organic compound that has been investigated for its potential
biomedical applications, particularly in drug discovery. Rhodanine derivatives have been …

[PDF][PDF] Antioxidant, anticancer and molecular docking studies of novel 5-benzylidene substituted rhodanine derivatives

C Mathew, N Lal, S Lakhsmi… - Int J Pharm …, 2023 - pdfs.semanticscholar.org
Objective: The primary objective was to study the in vitro antioxidant and anticancer
evaluation of novel 5-benzylidene substituted rhodanine derivatives and molecular docking …