Chemistry of pyridoxine in drug design

YG Shtyrlin, AS Petukhov, AD Strelnik… - Russian Chemical …, 2019 - Springer
Pyridoxine and its derivatives, pyridoxamine and pyridoxal, are the three main forms of
vitamin B 6, which play exceptionally important biological roles in living organisms. The …

Visible light-driven reductive azaarylation of coumarin-3-carboxylic acids

E Kowalska, A Artelska, A Albrecht - The Journal of Organic …, 2022 - ACS Publications
In the manuscript, reductive and decarboxylative azaarylation of coumarin-3-carboxylic
acids is described. It utilizes the photocatalytic activation of (cyano) azaarenes in the …

Synthesis and antibacterial activity of novel phosphonium salts on the basis of pyridoxine

MV Pugachev, NV Shtyrlin, LP Sysoeva… - Bioorganic & medicinal …, 2013 - Elsevier
A series of 13 phosphonium salts on the basis of pyridoxine derivatives were synthesized
and their antibacterial activity against clinically relevant strains was tested in vitro. All …

Pyridoxine‐derived organoselenium compounds with glutathione peroxidase‐like and chain‐breaking antioxidant activity

VP Singh, J Poon, RJ Butcher… - Chemistry–A European …, 2014 - Wiley Online Library
One of the vitamin B6 vitamers, pyridoxine, was modified to incorporate selenium in various
oxidation states in place of the methyl group in position 2. Such compounds were …

Effect of a bromo substituent on the glutathione peroxidase activity of a pyridoxine-like diselenide

VP Singh, J Poon, RJ Butcher, X Lu… - The Journal of …, 2015 - ACS Publications
In search for better mimics of the glutathione peroxidase enzymes, pyridoxine-like
diselenides 6 and 11, carrying a 6-bromo substituent, were prepared. Reaction of 2, 6 …

New quaternary ammonium pyridoxine derivatives: synthesis and antibacterial activity

SV Sapozhnikov, NV Shtyrlin, AR Kayumov… - Medicinal Chemistry …, 2017 - Springer
A diverse library of 34 new quaternary mono-ammonium and bis-ammonium pyridoxine
derivatives was synthesized, and their antibacterial activity against several clinically relevant …

Synthesis and Antibacterial Activity of Quaternary Ammonium 4‐Deoxypyridoxine Derivatives

NV Shtyrlin, SV Sapozhnikov… - BioMed research …, 2016 - Wiley Online Library
A series of novel quaternary ammonium 4‐deoxypyridoxine derivatives was synthesized.
Two compounds demonstrated excellent activity against a panel of Gram‐positive methicillin …

Turning pyridoxine into a catalytic chain-breaking and hydroperoxide-decomposing antioxidant

VP Singh, J Poon, L Engman - The Journal of Organic Chemistry, 2013 - ACS Publications
Vitamin B6 is involved in a variety of enzymatic transformations. Some recent findings also
indicate an antioxidant role of the vitamin in biological systems. We set out to turn pyridoxine …

Novel potent pyridoxine-based inhibitors of AChE and BChE, structural analogs of pyridostigmine, with improved in vivo safety profile

AD Strelnik, AS Petukhov, IV Zueva, VV Zobov… - Bioorganic & Medicinal …, 2016 - Elsevier
We report a novel class of carbamate-type ChE inhibitors, structural analogs of
pyridostigmine. A small library of congeneric pyridoxine-based compounds was designed …

[PDF][PDF] Synthesis and biological activity of quaternary phosphonium salts based on 3-hydroxypyridine and 4-deoxypyridoxine

NV Shtyrlin, RM Vafina, MV Pugachev… - Russian Chemical …, 2016 - researchgate.net
Nowadays, the area of application of quaternary phos phonium salts is very wide. In
particular, they are used as catalysts in enantioselective synthesis, 1—3 phase transfer …