Meta-hallmarks of aging and cancer

C López-Otín, F Pietrocola, D Roiz-Valle, L Galluzzi… - Cell metabolism, 2023 - cell.com
Both aging and cancer are characterized by a series of partially overlapping" hallmarks" that
we subject here to a meta-analysis. Several hallmarks of aging (ie, genomic instability …

Telomeres and telomere length: a general overview

N Srinivas, S Rachakonda, R Kumar - Cancers, 2020 - mdpi.com
Telomeres are highly conserved tandem nucleotide repeats that include proximal double-
stranded and distal single-stranded regions that in complex with shelterin proteins afford …

Association between telomere length and risk of cancer and non-neoplastic diseases: a Mendelian randomization study

PC Haycock, S Burgess, A Nounu, J Zheng… - JAMA …, 2017 - jamanetwork.com
Importance The causal direction and magnitude of the association between telomere length
and incidence of cancer and non-neoplastic diseases is uncertain owing to the susceptibility …

[HTML][HTML] Telomere length and all-cause mortality: a meta-analysis

Q Wang, Y Zhan, NL Pedersen, F Fang, S Hägg - Ageing research reviews, 2018 - Elsevier
Telomere attrition is associated with increased morbidity and mortality of various age-related
diseases. Reports of association between telomere length (TL) and all-cause mortality …

[HTML][HTML] The biology of aging and cancer: a brief overview of shared and divergent molecular hallmarks

JR Aunan, WC Cho, K Søreide - Aging and disease, 2017 - ncbi.nlm.nih.gov
Aging is the inevitable time-dependent decline in physiological organ function and is a
major risk factor for cancer development. Due to advances in health care, hygiene control …

Peripheral blood leukocyte telomere length and mortality among 64 637 individuals from the general population

L Rode, BG Nordestgaard… - Journal of the National …, 2015 - academic.oup.com
Background: Short telomeres in peripheral blood leukocytes are associated with older age
and age-related diseases. We tested the hypotheses that short telomeres are associated …

Gender and telomere length: systematic review and meta-analysis

M Gardner, D Bann, L Wiley, R Cooper, R Hardy… - Experimental …, 2014 - Elsevier
Background It is widely believed that females have longer telomeres than males, although
results from studies have been contradictory. Methods We carried out a systematic review …

Telomere biology and age-related diseases

M Herrmann, I Pusceddu, W März… - Clinical Chemistry and …, 2018 - degruyter.com
Telomeres are the protective end caps of chromosomes and shorten with every cell division.
Telomere length has been proposed as a biomarker of biological age and a risk factor for …

Telomere length variations in aging and age-related diseases

S Rizvi, ST Raza, F Mahdi - Current aging science, 2014 - ingentaconnect.com
Telomeres are gene sequences present at chromosomal ends and are responsible for
maintaining genome integrity. Telomere length is maximum at birth and decreases …

DNA methylation‐based biological aging and cancer risk and survival: Pooled analysis of seven prospective studies

PA Dugué, JK Bassett, JHE Joo… - … journal of cancer, 2018 - Wiley Online Library
The association between aging and cancer is complex. Recent studies have developed
measures of biological aging based on DNA methylation and called them “age …