T cells in health and disease
L Sun, Y Su, A Jiao, X Wang, B Zhang - Signal transduction and …, 2023 - nature.com
T cells are crucial for immune functions to maintain health and prevent disease. T cell
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …
development occurs in a stepwise process in the thymus and mainly generates CD4+ and …
PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program
Combination therapy with PD-1 blockade and IL-2 is highly effective during chronic
lymphocytic choriomeningitis virus infection. Here we examine the underlying basis for this …
lymphocytic choriomeningitis virus infection. Here we examine the underlying basis for this …
Single-cell multi-omics analysis of the immune response in COVID-19
Abstract Analysis of human blood immune cells provides insights into the coordinated
response to viral infections such as severe acute respiratory syndrome coronavirus 2, which …
response to viral infections such as severe acute respiratory syndrome coronavirus 2, which …
Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by temporal single-cell transcriptomics and epigenetics
Naïve CD8+ T cells can differentiate into effector (Teff), memory (Tmem) or exhausted (Tex)
T cells. These developmental pathways are associated with distinct transcriptional and …
T cells. These developmental pathways are associated with distinct transcriptional and …
PD-1-cis IL-2R agonism yields better effectors from stem-like CD8+ T cells
L Codarri Deak, V Nicolini, M Hashimoto, M Karagianni… - Nature, 2022 - nature.com
Expansion and differentiation of antigen-experienced PD-1+ TCF-1+ stem-like CD8+ T cells
into effector cells is critical for the success of immunotherapies based on PD-1 blockade …
into effector cells is critical for the success of immunotherapies based on PD-1 blockade …
Phenotype, specificity and avidity of antitumour CD8+ T cells in melanoma
G Oliveira, K Stromhaug, S Klaeger, T Kula… - Nature, 2021 - nature.com
Interactions between T cell receptors (TCRs) and their cognate tumour antigens are central
to antitumour immune responses,–; however, the relationship between phenotypic …
to antitumour immune responses,–; however, the relationship between phenotypic …
Rapid and stable mobilization of CD8+ T cells by SARS-CoV-2 mRNA vaccine
V Oberhardt, H Luxenburger, J Kemming, I Schulien… - Nature, 2021 - nature.com
SARS-CoV-2 spike mRNA vaccines,–mediate protection from severe disease as early as ten
days after prime vaccination, when neutralizing antibodies are hardly detectable,–. Vaccine …
days after prime vaccination, when neutralizing antibodies are hardly detectable,–. Vaccine …
Epigenetic regulation of T cell exhaustion
Chronic antigen stimulation during viral infections and cancer can lead to T cell exhaustion,
which is characterized by reduced effector function and proliferation, and the expression of …
which is characterized by reduced effector function and proliferation, and the expression of …
Transient rest restores functionality in exhausted CAR-T cells through epigenetic remodeling
INTRODUCTION More than 50% of patients treated with chimeric antigen receptor (CAR)–T
cells for B cell malignancies develop progressive disease after CAR therapy, and these …
cells for B cell malignancies develop progressive disease after CAR therapy, and these …