As a complicated process, aging is characterized by various changes at the cellular,
subcellular and nuclear levels, one of which is epigenetic aging. With increasing awareness …

BACKGROUND Modern reproductive behavior in most developed countries is characterized
by delayed parenthood. Older gametes are generally less fertile, accumulating and …

BACKGROUND A defining feature of sexual reproduction is the transmission of genomic
information from both parents to the offspring. There is now compelling evidence that the …

The notion that the germ line does not age goes back to the 19th-century ideas of August
Weismann. However, being metabolically active, the germ line accumulates damage and …

Aging as an irretrievable occurrence throughout the entire life is characterized by a
progressive decline in physiological functionality and enhanced disease vulnerability …

Abstract Forensic DNA Phenotyping (FDP) comprises the prediction of a person's externally
visible characteristics regarding appearance, biogeographic ancestry and age from DNA of …

Background There is a global crisis in male reproductive health. Evidence comes from
globally declining sperm counts and increasing male reproductive system abnormalities …

BACKGROUND Studies in non-human mammals suggest that environmental factors can
influence spermatozoal DNA methylation, and some research suggests that spermatozoal …

Cells may naturally proceed or be forced to transition to a state with a radically lower
biological age, that is, be rejuvenated. Examples are the conversion of somatic cells to …

Recent research revealed a rejuvenation event during early development of mice. Here, by
examining epigenetic age dynamics of human embryogenesis, we tested whether a similar …