GRB2 dimerization mediated by SH2 domain-swapping is critical for T cell signaling and cytokine production
A Sandouk, Z Xu, S Baruah, M Tremblay, JB Hopkins… - Scientific reports, 2023 - nature.com
GRB2 is an adaptor protein required for facilitating cytoplasmic signaling complexes from a
wide array of binding partners. GRB2 has been reported to exist in either a monomeric or …
wide array of binding partners. GRB2 has been reported to exist in either a monomeric or …
Exploring the roles of proline in three-dimensional domain swapping from structure analysis and molecular dynamics simulations
Y Huang, M Gao, Z Su - The Protein Journal, 2018 - Springer
Abstract Three-dimensional (3D) domain swapping is a mechanism to form protein
oligomers. It has been proposed that several factors, including proline residues in the hinge …
oligomers. It has been proposed that several factors, including proline residues in the hinge …
SH2/SH2-Mediated Domain-Swapped Dimerization of GRB2 and Its Implications for GRB2 Function
A Sandouk - 2023 - search.proquest.com
GRB2 is an adaptor protein required for facilitating cytoplasmic signaling complexes from a
wide array of binding partners. GRB2 has been reported to exist in either a monomeric or …
wide array of binding partners. GRB2 has been reported to exist in either a monomeric or …
Reducing discrepancies between 3D and 2D simulations due to cell packing density
Modelling all three spatial dimensions is often much more computationally expensive than
modelling a two-dimensional simplification of the same system. Researchers comparing …
modelling a two-dimensional simplification of the same system. Researchers comparing …
[图书][B] Understanding biopharmaceutical aggregation using minimalist models based on square-well potential
HJ Magnier - 2016 - search.proquest.com
Protein misfolding and aggregation are the cause of many problems within the
biopharmaceutical industry and medical fields. Although many experimental studies have …
biopharmaceutical industry and medical fields. Although many experimental studies have …
Monte Carlo simulation approaches to protein stability and aggregation prediction
JC Woodard - 2017 - search.proquest.com
A protein's sequence and set of covalent modifications determine its stability and
aggregation propensity in a given environment. Given a change in sequence or covalent …
aggregation propensity in a given environment. Given a change in sequence or covalent …