Post-translational modification by Small Ubiquitin-like Modifier (SUMO) proteins regulates
numerous cellular processes. This modification involves the covalent and reversible …

Acute promyelocytic leukemia (APL) is driven by a chromosomal translocation whose
product, the PML/retinoic acid (RA) receptor α (RARA) fusion protein, affects both nuclear …

The promyelocytic leukemia (PML) protein organizes PML nuclear bodies (NBs), which are
stress-responsive domains where many partner proteins accumulate. Here, we clarify the …

In contrast to our extensive knowledge on covalent small ubiquitin-like modifier (SUMO)
target proteins, we are limited in our understanding of non-covalent SUMO-binding proteins …

Spatial organization of cellular processes in membranous or membrane-less organelles
(MLOs, alias molecular condensates) is a key concept for compartmentalizing biochemical …

PML Nuclear Bodies (NBs) have fascinated cell biologists due to their exquisitely dynamic
nature and their involvement in human diseases, notably acute promyelocytic leukemia …

The Homeodomain-interacting protein kinase (Hipk) family of proteins plays diverse, and at
times conflicting, biological roles in normal development and disease. In this review we will …

In response to DNA‐damage, cells have to decide between different cell fate programmes.
Activation of the tumour suppressor HIPK2 specifies the DNA damage response (DDR) and …

PML and several other proteins localizing in PML-nuclear bodies (PML-NB) contain
phosphoSIMs (SUMO-interacting motifs), and phosphorylation of this motif plays a key role …

Promyelocytic leukemia protein (PML) nuclear bodies (NBs), which are sub-nuclear protein
structures, are involved in a variety of important cellular functions. PML-NBs are assembled …