The roles of FLT3 in hematopoiesis and leukemia
DG Gilliland, JD Griffin - Blood, The Journal of the American …, 2002 - ashpublications.org
FLT3 is a receptor tyrosine kinase expressed by immature hematopoietic cells and is
important for the normal development of stem cells and the immune system. The ligand for …
important for the normal development of stem cells and the immune system. The ligand for …
The Flt3L/Flt3 axis in dendritic cell biology and cancer immunotherapy
Simple Summary Cancer immunotherapy is currently focused mainly on the enhancement of
the effector function of T cells. However, dendritic cells (DCs) are needed to prime T cells …
the effector function of T cells. However, dendritic cells (DCs) are needed to prime T cells …
Role of FLT3 in leukemia
DG Gilliland, JD Griffin - Current opinion in hematology, 2002 - journals.lww.com
FLT3 is the most frequently mutated gene in cases of acute myelogenous leukemia (AML).
About 30 to 35% of patients have either internal tandem duplications (ITDs) in the …
About 30 to 35% of patients have either internal tandem duplications (ITDs) in the …
[PDF][PDF] FLT3L-dependent dendritic cells control tumor immunity by modulating Treg and NK cell homeostasis
P Regnier, M Vetillard, A Bansard, E Pierre, X Li… - Cell Reports …, 2023 - cell.com
FLT3-L-dependent classical dendritic cells (cDCs) recruit anti-tumor and tumor-protecting
lymphocytes. We evaluate cancer growth in mice with low, normal, or high levels of cDCs …
lymphocytes. We evaluate cancer growth in mice with low, normal, or high levels of cDCs …
Comparative analysis of murine marrow–derived dendritic cells generated by Flt3L or GM-CSF/IL-4 and matured with immune stimulatory agents on the in vivo …
BJ Weigel, N Nath, PA Taylor… - Blood, The Journal …, 2002 - ashpublications.org
Bone marrow (BM)–derived dendritic cells (DCs) cultured in granulocyte-macrophage
colony-stimulating factor (GM-CSF) and interleukin 4 (IL-4) have been used to generate …
colony-stimulating factor (GM-CSF) and interleukin 4 (IL-4) have been used to generate …
Flt3L and TK gene therapy eradicate multifocal glioma in a syngeneic glioblastoma model
GD King, AKMG Muhammad, JF Curtin… - Neuro …, 2008 - academic.oup.com
The disseminated characteristics of human glioblastoma multiforme (GBM) make it a
particularly difficult tumor to treat with long-term efficacy. Most preclinical models of GBM …
particularly difficult tumor to treat with long-term efficacy. Most preclinical models of GBM …
[HTML][HTML] Flt3 ligand and granulocyte-macrophage colony-stimulating factor preferentially expand and stimulate different dendritic and T-cell subsets
OBJECTIVE: Mechanisms of T-cell stimulation by Flt3 ligand (Flt3L) and granulocyte-
macrophage colony-stimulating factor (GM-CSF) remain unclear. Herein, we compared the …
macrophage colony-stimulating factor (GM-CSF) remain unclear. Herein, we compared the …
[HTML][HTML] Src family tyrosine kinases are activated by Flt3 and are involved in the proliferative effects of leukemia-associated Flt3 mutations
LJ Robinson, J Xue, SJ Corey - Experimental hematology, 2005 - Elsevier
OBJECTIVE: The hematopoietic growth factor receptor, Fms-like tyrosine kinase-3 (Flt3),
modulates survival and proliferation of myeloid and B-cell precursors. Activating mutations of …
modulates survival and proliferation of myeloid and B-cell precursors. Activating mutations of …
Myeloid-derived suppressor cells: their role in the pathophysiology of hematologic malignancies and potential as therapeutic targets
IH Younos, F Abe, JE Talmadge - Leukemia & Lymphoma, 2015 - Taylor & Francis
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature
myeloid cells at various stages of differentiation/maturation that have a role in cancer …
myeloid cells at various stages of differentiation/maturation that have a role in cancer …
In vitro tumor-pulsed or in vivo Flt3 ligand–generated dendritic cells provide protection against acute myelogenous leukemia in nontransplanted or syngeneic bone …
AB Pawlowska, S Hashino, H McKenna… - Blood, The Journal …, 2001 - ashpublications.org
To determine whether immune stimulation could reduce acute myelogenous leukemia
(AML) lethality, dendritic cells (DCs) were pulsed with AML antigens and used as vaccines …
(AML) lethality, dendritic cells (DCs) were pulsed with AML antigens and used as vaccines …