The fungal pathogen Candida albicans must acquire phosphate to colonize, infect, and
proliferate in the human host. C. albicans has four inorganic phosphate (Pi) transporters …

In the human-pathogenic fungus Cryptococcus neoformans, the inositol polyphosphate
signaling pathway is critical for virulence. We recently demonstrated the key role of the …

Cryptococcus neoformans is a ubiquitous, opportunistic fungal pathogen that kills almost
200,000 people worldwide each year. It is acquired when mammalian hosts inhale the …

Fission yeast phosphate homeostasis entails transcriptional induction of genes encoding
phosphate-mobilizing proteins under conditions of phosphate starvation. Transcription factor …

Inositol tris/tetrakis phosphate kinases (IP3-4K) in the human fungal priority pathogens,
Cryptococcus neoformans (Cn Arg1) and Candida albicans (Ca Ipk2), convey numerous …

Fungal pathogens uniquely regulate phosphate homeostasis via the cyclin-dependent
kinase (CDK) signaling machinery of the phosphate acquisition (PHO) pathway (Pho85 …

The model yeast Saccharomyces cerevisiae elicits a transcriptional response to phosphate
(P i) depletion. To determine the origins of the phosphate response (PHO) system, we …

The ability of pathogenic fungi to obtain essential nutrients from the host is vital for virulence.
In Candida albicans, acquisition of the macronutrient phosphate is regulated by the Pho4 …

In the human-pathogenic fungus Cryptococcus neoformans, the inositol polyphosphate
signaling pathway is critical for virulence. We recently demonstrated the key role of the …

Fungal pathogens uniquely regulate phosphate homeostasis via the cyclindependent
kinase (CDK) signaling machinery of the phosphate acquisition (PHO) pathway (Pho85 …