The involvement of Reelin in neurodevelopmental disorders
TD Folsom, SH Fatemi - Neuropharmacology, 2013 - Elsevier
Reelin is a glycoprotein that serves important roles both during development (regulation of
neuronal migration and brain lamination) and in adulthood (maintenance of synaptic …
neuronal migration and brain lamination) and in adulthood (maintenance of synaptic …
Reelin through the years: From brain development to inflammation
Reelin was originally identified as a regulator of neuronal migration and synaptic function,
but its non-neuronal functions have received far less attention. Reelin participates in organ …
but its non-neuronal functions have received far less attention. Reelin participates in organ …
Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study
Background Reelin (RELN) is a glycoprotein secreted preferentially by cortical γ-
aminobutyric acid-ergic (GABAergic) interneurons (layers I and II) that binds to integrin …
aminobutyric acid-ergic (GABAergic) interneurons (layers I and II) that binds to integrin …
Glutamic acid decarboxylase 65 and 67 kDa proteins are reduced in autistic parietal and cerebellar cortices
BACKGROUND: A limited number of reports have demonstrated abnormalities involving the
glutamate and gamma amino butyric acid systems in blood and platelets of subjects with …
glutamate and gamma amino butyric acid systems in blood and platelets of subjects with …
Reelin promoter hypermethylation in schizophrenia
DR Grayson, X Jia, Y Chen… - Proceedings of the …, 2005 - National Acad Sciences
Reelin mRNA and protein levels are reduced by≈ 50% in various cortical structures of
postmortem brain from patients diagnosed with schizophrenia or bipolar illness with …
postmortem brain from patients diagnosed with schizophrenia or bipolar illness with …
Reduction in Reelin immunoreactivity in hippocampus of subjects with schizophrenia, bipolar disorder and major depression
SH Fatemi, JA Earle, T McMenomy - Molecular psychiatry, 2000 - nature.com
Accumulation of neurobiological knowledge points to neurodevelopmental origins for certain
psychotic and mood disorders. Recent landmark postmortem reports implicate Reelin, a …
psychotic and mood disorders. Recent landmark postmortem reports implicate Reelin, a …
An epigenetic mouse model for molecular and behavioral neuropathologies related to schizophrenia vulnerability
Reelin and glutamic acid decarboxylase (GAD) 67 expressed by cortical γ-aminobutyric acid-
ergic interneurons are down-regulated in schizophrenia. Because epidemiological studies …
ergic interneurons are down-regulated in schizophrenia. Because epidemiological studies …
DNA-methyltransferase 1 mRNA is selectively overexpressed in telencephalic GABAergic interneurons of schizophrenia brains
M Veldic, HJ Caruncho, WS Liu… - Proceedings of the …, 2004 - National Acad Sciences
A down-regulation of reelin and glutamic acid decarboxylase (GAD) 67 mRNAs was
detected in γ-aminobutyric acid (GABA) ergic cortical interneurons of schizophrenia (SZ) …
detected in γ-aminobutyric acid (GABA) ergic cortical interneurons of schizophrenia (SZ) …
Reelin signaling is impaired in autism
BACKGROUND: Autism is a severe neurodevelopmental disorder with genetic and
environmental etiologies. Recent genetic linkage studies implicate Reelin glycoprotein in …
environmental etiologies. Recent genetic linkage studies implicate Reelin glycoprotein in …
GABAergic dysfunction in schizophrenia and mood disorders as reflected by decreased levels of glutamic acid decarboxylase 65 and 67 kDa and Reelin proteins in …
Background: Glutamic acid decarboxylase (GAD) is the rate limiting enzyme responsible for
conversion of glutamate to gamma-aminobutyric acid (GABA) regulating levels of glutamate …
conversion of glutamate to gamma-aminobutyric acid (GABA) regulating levels of glutamate …