Since the identification and definition of the hallmarks of aging, these aspects of molecular and cellular decline have been most often described as isolated or distinct mechanisms …
Mitochondrial oxidative phosphorylation (OXPHOS) complexes are assembled from proteins encoded by both nuclear and mitochondrial DNA. These dual-origin enzymes pose a …
Traditionally, mitochondria are known as" the powerhouse of the cell," responsible for energy (ATP) generation (by the electron transport chain, oxidative phosphorylation, the …
The human population is aging, and the need for interventions to slow progression of age- related diseases (geroprotective interventions) is growing. Repurposing compounds already …
J Ma, L Sun, W Gao, Y Li, D Dong - Journal of Translational Medicine, 2023 - Springer
Mitochondria are the only organelles regulated by two genomes. The coordinated translation of nuclear DNA (nDNA) and mitochondrial DNA (mtDNA), which together co …
T Pfannschmidt, MJ Terry… - … Transactions of the …, 2020 - royalsocietypublishing.org
Endosymbiotic organelles of eukaryotic cells, the plastids, including chloroplasts and mitochondria, are highly integrated into cellular signalling networks. In both heterotrophic …
NJ Kramer, G Prakash, K Choquet, I Soto, B Petrova… - bioRxiv, 2023 - biorxiv.org
Mitochondrial oxidative phosphorylation (OXPHOS) complexes are assembled from proteins encoded by both nuclear and mitochondrial DNA. These dual-origin enzymes pose a …
HK Chen, YW Hsieh, HY Hsu, TY Liu… - BMC Medical …, 2024 - ncbi.nlm.nih.gov
Background Previous studies have implicated inherited mutations in mitochondrial DNA (mtDNA) in sensorineural hearing loss (SNHL). However, the definitive association between …
La durée de vie des animaux varie grandement au sein du règne animal, et ce fait intrigue et captive les biologistes particulièrement depuis plusieurs décennies. Les mécanismes qui …