[HTML][HTML] The central role of mitochondrial fitness on antiviral defenses: An advocacy for physical activity during the COVID-19 pandemic

J Burtscher, M Burtscher, GP Millet - Redox biology, 2021 - Elsevier
Mitochondria are central regulators of cellular metabolism, most known for their role in
energy production. They can be “enhanced” by physical activity (including exercise), which …

Integrating the hallmarks of aging throughout the tree of life: a focus on mitochondrial dysfunction

S Van der Rijt, M Molenaars, RL McIntyre… - Frontiers in cell and …, 2020 - frontiersin.org
Since the identification and definition of the hallmarks of aging, these aspects of molecular
and cellular decline have been most often described as isolated or distinct mechanisms …

Regulators of mitonuclear balance link mitochondrial metabolism to mtDNA expression

NJ Kramer, G Prakash, RS Isaac, K Choquet, I Soto… - Nature Cell …, 2023 - nature.com
Mitochondrial oxidative phosphorylation (OXPHOS) complexes are assembled from proteins
encoded by both nuclear and mitochondrial DNA. These dual-origin enzymes pose a …

[HTML][HTML] Mitochondria as intracellular signalling organelles. An update

LD Popov - Cellular Signalling, 2023 - Elsevier
Traditionally, mitochondria are known as" the powerhouse of the cell," responsible for
energy (ATP) generation (by the electron transport chain, oxidative phosphorylation, the …

Anti-retroviral treatment with zidovudine alters pyrimidine metabolism, reduces translation, and extends healthy longevity via ATF-4

RL McIntyre, M Molenaars, BV Schomakers, AW Gao… - Cell reports, 2023 - cell.com
The human population is aging, and the need for interventions to slow progression of age-
related diseases (geroprotective interventions) is growing. Repurposing compounds already …

RNA binding protein: coordinated expression between the nuclear and mitochondrial genomes in tumors

J Ma, L Sun, W Gao, Y Li, D Dong - Journal of Translational Medicine, 2023 - Springer
Mitochondria are the only organelles regulated by two genomes. The coordinated
translation of nuclear DNA (nDNA) and mitochondrial DNA (mtDNA), which together co …

Retrograde signals from endosymbiotic organelles: a common control principle in eukaryotic cells

T Pfannschmidt, MJ Terry… - … Transactions of the …, 2020 - royalsocietypublishing.org
Endosymbiotic organelles of eukaryotic cells, the plastids, including chloroplasts and
mitochondria, are highly integrated into cellular signalling networks. In both heterotrophic …

Genome-wide screens for mitonuclear co-regulators uncover links between compartmentalized metabolism and mitochondrial gene expression

NJ Kramer, G Prakash, K Choquet, I Soto, B Petrova… - bioRxiv, 2023 - biorxiv.org
Mitochondrial oxidative phosphorylation (OXPHOS) complexes are assembled from proteins
encoded by both nuclear and mitochondrial DNA. These dual-origin enzymes pose a …

[HTML][HTML] Increased risk of hearing loss associated with MT-RNR1 gene mutations: a real-world investigation among Han Taiwanese Population

HK Chen, YW Hsieh, HY Hsu, TY Liu… - BMC Medical …, 2024 - ncbi.nlm.nih.gov
Background Previous studies have implicated inherited mutations in mitochondrial DNA
(mtDNA) in sensorineural hearing loss (SNHL). However, the definitive association between …

Modulation de la longévité et architecture du système de transfert des électrons chez les bivalves marins

E Rodriguez - 2021 - semaphore.uqar.ca
La durée de vie des animaux varie grandement au sein du règne animal, et ce fait intrigue et
captive les biologistes particulièrement depuis plusieurs décennies. Les mécanismes qui …