Core protein: A pleiotropic keystone in the HBV lifecycle

A Zlotnick, B Venkatakrishnan, Z Tan, E Lewellyn… - Antiviral research, 2015 - Elsevier
Abstract Hepatitis B Virus (HBV) is a small virus whose genome has only four open reading
frames. We argue that the simplicity of the virion correlates with a complexity of functions for …

Capsid assembly modulators as antiviral agents against HBV: molecular mechanisms and clinical perspectives

V Taverniti, G Ligat, Y Debing, DB Kum… - Journal of clinical …, 2022 - mdpi.com
Despite a preventive vaccine being available, more than 250 million people suffer from
chronic hepatitis B virus (HBV) infection, a major cause of liver disease and HCC. HBV …

The crystal structure of the human hepatitis B virus capsid

SA Wynne, RA Crowther, AGW Leslie - Molecular cell, 1999 - cell.com
Hepatitis B is a small enveloped DNA virus that poses a major hazard to human health. The
crystal structure of the T= 4 capsid has been solved at 3.3 Å resolution, revealing a largely …

Targeting the multifunctional HBV core protein as a potential cure for chronic hepatitis B

U Viswanathan, N Mani, Z Hu, H Ban, Y Du, J Hu… - Antiviral research, 2020 - Elsevier
The core (capsid) protein of hepatitis B virus (HBV) is the building block of nucleocapsids
where viral DNA reverse transcriptional replication takes place and mediates virus-host cell …

Weak protein− protein interactions are sufficient to drive assembly of hepatitis B virus capsids

P Ceres, A Zlotnick - Biochemistry, 2002 - ACS Publications
Hepatitis B virus (HBV) is an enveloped DNA virus with a spherical capsid (or core). The
capsid is constructed from 120 copies of the homodimeric capsid protein arranged with T= 4 …

Adding the third dimension to virus life cycles: three-dimensional reconstruction of icosahedral viruses from cryo-electron micrographs

TS Baker, NH Olson, SD Fuller - Microbiology and Molecular …, 1999 - Am Soc Microbiol
Viruses are cellular parasites. The linkage between viral and host functions makes the study
of a viral life cycle an important key to cellular functions. A deeper understanding of many …

[HTML][HTML] Hepatitis B virus morphogenesis

V Bruss - World journal of gastroenterology: WJG, 2007 - ncbi.nlm.nih.gov
The hepatitis B virus (HBV) particle consists of an envelope containing three related surface
proteins and probably lipid and an icosahedral nucleocapsid of approximately 30 nm …

Characterization of the intracellular deproteinized relaxed circular DNA of hepatitis B virus: an intermediate of covalently closed circular DNA formation

H Guo, D Jiang, T Zhou, A Cuconati, TM Block… - Journal of …, 2007 - Am Soc Microbiol
Covalently closed circular DNA (cccDNA) of hepatitis B virus (HBV) is formed by conversion
of capsid-associated relaxed circular DNA (rcDNA) via unknown mechanisms and exists in …

Nuclear import of hepatitis B virus capsids and release of the viral genome

B Rabe, A Vlachou, N Panté… - Proceedings of the …, 2003 - National Acad Sciences
While studying the import of the hepatitis B virus genome into the nucleus of permeabilized
tissue culture cells, we found that viral capsids were imported in intact form through the …

The structural biology of hepatitis B virus: form and function

B Venkatakrishnan, A Zlotnick - Annual review of virology, 2016 - annualreviews.org
Hepatitis B virus is one of the smallest human pathogens, encoded by a 3,200-bp genome
with only four open reading frames. Yet the virus shows a remarkable diversity in structural …