Group II introns: mobile ribozymes that invade DNA

AM Lambowitz, S Zimmerly - Cold Spring Harbor …, 2011 - cshperspectives.cshlp.org
Group II introns are mobile ribozymes that self-splice from precursor RNAs to yield excised
intron lariat RNAs, which then invade new genomic DNA sites by reverse splicing. The …

Mobile group II introns

AM Lambowitz, S Zimmerly - Annu. Rev. Genet., 2004 - annualreviews.org
▪ Abstract Mobile group II introns, found in bacterial and organellar genomes, are both
catalytic RNAs and retrotransposable elements. They use an extraordinary mobility …

Evolution of group II introns

S Zimmerly, C Semper - Mobile DNA, 2015 - Springer
Present in the genomes of bacteria and eukaryotic organelles, group II introns are an
ancient class of ribozymes and retroelements that are believed to have been the ancestors …

Mobile bacterial group II introns at the crux of eukaryotic evolution

AM Lambowitz, M Belfort - Mobile DNA III, 2015 - Wiley Online Library
Group II introns are remarkable mobile retroelements that use the combined activities of an
autocatalytic RNA and an intron‐encoded reverse transcriptase (RT) to propagate efficiently …

Use of computer-designed group II introns to disrupt Escherichia coli DExH/D-box protein and DNA helicase genes

J Perutka, W Wang, D Goerlitz… - Journal of molecular …, 2004 - Elsevier
Mobile group II introns are site-specific retroelements that use a novel mobility mechanism in
which the excised intron RNA inserts directly into a DNA target site and is then reverse …

Complete nucleotide sequence of pHG1: a Ralstonia eutropha H16 megaplasmid encoding key enzymes of H2-based lithoautotrophy and anaerobiosis

E Schwartz, A Henne, R Cramm, T Eitinger… - Journal of molecular …, 2003 - Elsevier
The self-transmissible megaplasmid pHG1 carries essential genetic information for the
facultatively lithoautotrophic and facultatively anaerobic lifestyles of its host, the Gram …

Group II intron self-splicing

AM Pyle - Annual Review of Biophysics, 2016 - annualreviews.org
Group II introns are large, autocatalytic ribozymes that catalyze RNA splicing and
retrotransposition. Splicing by group II introns plays a major role in the metabolism of plants …

Biotechnological applications of mobile group II introns and their reverse transcriptases: gene targeting, RNA-seq, and non-coding RNA analysis

PJ Enyeart, G Mohr, AD Ellington, AM Lambowitz - Mobile DNA, 2014 - Springer
Mobile group II introns are bacterial retrotransposons that combine the activities of an
autocatalytic intron RNA (a ribozyme) and an intron-encoded reverse transcriptase to insert …

Group II introns: structure and catalytic versatility of large natural ribozymes

K Lehmann, U Schmidt - Critical reviews in biochemistry and …, 2003 - Taylor & Francis
Group II introns are large, natural catalytic RNAs or ribozymes that were discovered in
organelles of certain protists, fungi, algae, and plants and more recently also in prokaryotic …

Characterization of the C-terminal DNA-binding/DNA endonuclease region of a group II intron-encoded protein

J San Filippo, AM Lambowitz - Journal of molecular biology, 2002 - Elsevier
Group II intron retrohoming occurs by a mechanism in which the intron RNA reverse splices
directly into one strand of a double-stranded DNA target site, while the intron-encoded …