Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder caused by the loss
of motor neurons from the brain and spinal cord. The ALS community has made remarkable …

Amyotrophic lateral sclerosis (ALS) is the most common adult-onset paralytic disorder,
characterized mainly by a loss of motor neurons (MNs) in the CNS. Over the past decades …

Amyotrophic lateral sclerosis (ALS) is caused by selective degeneration of motor neurons in
the brain and spinal cord; however, the primary cell death pathway (s) mediating motor …

Despite wide genetic, environmental and clinical heterogeneity in amyotrophic lateral
sclerosis, a rapidly fatal neurodegenerative disease targeting motoneurons …

Necroptosis is a lytic form of cell death that is mediated by the kinase RIPK3 and the
pseudokinase MLKL when caspase-8 is inhibited downstream of death receptors, toll-like …

Motor neuron degeneration in amyotrophic lateral sclerosis (ALS) is proposed to occur by
necroptosis, an inflammatory form of regulated cell death. Prior studies implicated …

Necroptosis is a lytic, inflammatory cell death pathway that is dysregulated in many human
pathologies. The pathway is executed by a core machinery comprising the RIPK1 and …

Amyotrophic lateral sclerosis (ALS) is a debilitating and rapidly fatal neurodegenerative
disease. Despite decades of research and many new insights into disease biology over the …

Necroptosis, a regulated form of cell death, is involved in the genesis and development of
various life-threatening diseases, including cancer, neurological disorders, cardiac …

Myofibre necrosis is a central pathogenic process in muscular dystrophies (MD). As post-
lesional regeneration cannot fully compensate for chronic myofibre loss, interstitial tissue …