Enzymatic reactions and noncovalent (ie, supramolecular) interactions are two fundamental
nongenetic attributes of life. Enzymatic noncovalent synthesis (ENS) refers to a process …

The abscission checkpoint contributes to the fidelity of chromosome segregation by delaying
completion of cytokinesis (abscission) when there is chromatin lagging in the intercellular …

Long ignored as a vestigial remnant of cytokinesis, the mammalian midbody (MB) is
released post-abscission inside large extracellular vesicles called MB remnants (MBRs) …

Breast cancer is the most common cancer and the leading cause of cancer-related deaths in
women. Increasing molecular targets have been discovered for breast cancer prognosis and …

INTRODUCTION In response to aging, senescence plays a major role in the onset of various
degenerative diseases, including the slow development of cataracts, a clouding of the eye …

Cytokinesis requires the constriction of ESCRT-III filaments on the side of the midbody,
where abscission occurs. After ESCRT recruitment at the midbody, it is not known how the …

Cell‐derived extracellular vesicles (EVs) are evolutionary‐conserved secretory organelles
that, based on their molecular composition, are important intercellular signaling regulators …

Exosomes are small extracellular vesicles that originate from the intraluminal vesicles of
multivesicular bodies (MVBs). We previously reported that polarized Madin-Darby canine …

Calcium (Ca2+) can regulate a wide variety of cellular fates, such as proliferation, apoptosis,
and autophagy. More importantly, changes in the intracellular Ca2+ level can modulate …

Cytokinetic abscission leads to the physical cut of the intercellular bridge (ICB) connecting
the daughter cells and concludes cell division. In different animal cells, it is well established …