Certain transcription factors have vital roles in lineage development, including specification
of cell types and control of differentiation. Microphthalmia-associated transcription factor …

MITF (microphthalmia-associated transcription factor) represents a melanocytic lineage-
specific transcription factor whose role is profoundly extended in malignant melanoma. Over …

Melanoma is a cutaneous neoplastic growth of melanocytes with great potential to invade
and metastasize, especially when not treated early and effectively. Epithelial-mesenchymal …

Tumour metastasis is a multistep process. Melanoma is a highly aggressive cancer and
metastasis accounts for the majority of patient deaths. microRNAs (miRNAs) are non-coding …

Melanoma is a therapy-resistant skin cancer due to numerous mechanisms supporting cell
survival. Although components of melanoma cytoprotective mechanisms are overexpressed …

Abstract Treatment resistance in metastatic melanoma is a longstanding issue. Current
targeted therapy regimes in melanoma largely target the proliferating cancer population …

Cutaneous melanoma (CM) and uveal melanoma (UM) both originate from the melanocytic
lineage but are primarily driven by distinct oncogenic drivers, BRAF/NRAS or GNAQ/GNA11 …

The POU domain family of transcription factors play a central role in embryogenesis and are
highly expressed in neural crest cells and the developing brain. BRN 2 is a class III POU …

Melanoma tumors are highly heterogeneous, comprising of different cell types that vary in
their potential for growth and invasion. Heterogeneous expression of the Microphthalmia …

Melanoma cells are notorious for their high plasticity and ability to switch back and forth
between various melanoma cell states, enabling the adaptation to sub-optimal conditions …