Drug resistance during HIV pre-exposure prophylaxis

KM Gibas, P van den Berg, VE Powell, DS Krakower - Drugs, 2019 - Springer
Clinical studies have demonstrated that use of tenofovir disoproxil fumarate with or without
emtricitabine as antiretroviral pre-exposure prophylaxis (PrEP) can decrease the risk of …

Pre-exposure prophylaxis (PrEP) in an era of stalled HIV prevention: Can it change the game?

R Eakle, F Venter, H Rees - Retrovirology, 2018 - Springer
Pre-exposure prophylaxis (PrEP) for HIV prevention has evolved significantly over the years
where clinical trials have now demonstrated the efficacy of oral PrEP, and the field is scaling …

Risk perception, sexual behaviors, and PrEP adherence among substance-using men who have sex with men: a qualitative study

ED Storholm, JE Volk, JL Marcus, MJ Silverberg… - Prevention …, 2017 - Springer
The antiretroviral drug combination emtricitabine and tenofovir disoproxil fumarate
(TDF/FTC) taken as pre-exposure prophylaxis (PrEP) is effective in preventing HIV infection …

Oral pre-exposure prophylaxis (PrEP) for prevention of HIV in serodiscordant heterosexual couples in the United States: opportunities and challenges

JM McMahon, JE Myers, AE Kurth… - AIDS patient care and …, 2014 - liebertpub.com
Oral HIV pre-exposure prophylaxis (PrEP) is a promising new biomedical prevention
approach in which HIV-negative individuals are provided with daily oral antiretroviral …

Population-level mathematical modeling of antimicrobial resistance: a systematic review

AM Niewiadomska, B Jayabalasingham, JC Seidman… - BMC medicine, 2019 - Springer
Background Mathematical transmission models are increasingly used to guide public health
interventions for infectious diseases, particularly in the context of emerging pathogens; …

Future technologies for monitoring HIV drug resistance and cure

UM Parikh, K McCormick, G van Zyl… - Current Opinion in HIV …, 2017 - journals.lww.com
Current population genotyping methods for resistance monitoring are high cost and low
throughput. NGS, combined with simpler sample collection and storage matrices (eg dried …

Should we fear resistance from tenofovir/emtricitabine preexposure prophylaxis?

UM Parikh, JW Mellors - Current opinion in HIV and AIDS, 2016 - journals.lww.com
The benefit of preventing HIV-1 infections with TDF/FTC PrEP far outweighs the risk of drug-
resistant infection, provided PrEP is not started in persons with undiagnosed HIV-1 infection …

Pre-exposure prophylaxis and antiretroviral resistance: HIV prevention at a cost?

CB Hurt, JJ Eron Jr, MS Cohen - Clinical Infectious Diseases, 2011 - academic.oup.com
Abstract Pre-exposure prophylaxis (PrEP), the use of antiretrovirals (ARVs) by human
immunodeficiency virus (HIV)–uninfected individuals to prevent acquisition of the virus …

Who would use PrEP? Factors associated with intention to use among MSM in London: a community survey

A Aghaizu, D Mercey, A Copas, AM Johnson… - Sexually transmitted …, 2013 - sti.bmj.com
Objective To assess current and intended future use of pre-exposure prophylaxis (PrEP)
among men who have sex with men (MSM) and characterise those attending sexual health …

Preexposure prophylaxis will have a limited impact on HIV-1 drug resistance in sub-Saharan Africa: a comparison of mathematical models

DAMC Van De Vijver, BE Nichols, UL Abbas… - Aids, 2013 - journals.lww.com
Background: Preexposure prophylaxis (PrEP) with tenofovir and emtricitabine can prevent
new HIV-1 infections, but there is a concern that use of PrEP could increase HIV drug …