Proline, the only proteinogenic secondary amino acid, is metabolized by its own family of
enzymes responding to metabolic stress and participating in metabolic signaling. Collagen …

The resurgence of interest in tumor metabolism has led investigators to emphasize the
metabolism of proline as a “stress substrate” and to suggest this pathway as a potential anti …

Following its predecessor, the second edition of Amino Acids: Biochemistry and Nutrition
presents exhaustive coverage of amino acids in the nutrition, metabolism and health of …

Abstract Prolidase [EC. 3.4. 13.9] is a cytosolic imidodipeptidase, which specifically splits
imidodipeptides with C-terminal proline or hydroxyproline. The enzyme plays an important …

Prolidase is a ubiquitous enzyme that plays a major role in the metabolism of proline-rich
proteins. Prolidase deficiency is a rare autosomal recessive inborn metabolic and …

Proline plays a special role in cancer metabolism. Proline oxidase (POX), aka proline
dehydrogenase (PRODH), is among a few genes induced rapidly and robustly by P53, the …

Background Prolidase deficiency (PD) is an autosomal recessive inborn multisystemic
disease caused by mutations in the PEPD gene encoding the enzyme prolidase D, leading …

Prolidase is a metal-dependent peptidase specialized in the cleavage of dipeptides
containing proline or hydroxyproline on their C-termini. Prolidase homologues are found in …

Recent reports have indicated prolidase (PEPD) as a ligand of the epidermal growth factor
receptor (EGFR). Since this receptor is involved in the promotion of cell proliferation, growth …

Point mutations resulting in the substitution of a single amino acid can cause severe
functional consequences, but can also be completely harmless. Understanding what …