Biological functions of mesenchymal stem cells and clinical implications

A Naji, M Eitoku, B Favier, F Deschaseaux… - Cellular and Molecular …, 2019 - Springer
Mesenchymal stem cells (MSCs) are isolated from multiple biological tissues—adult bone
marrow and adipose tissues and neonatal tissues such as umbilical cord and placenta. In …

Manufacturing human mesenchymal stem cells at clinical scale: process and regulatory challenges

V Jossen, C van den Bos, R Eibl, D Eibl - Applied microbiology and …, 2018 - Springer
Human mesenchymal stem cell (hMSC)-based therapies are of increasing interest in the
field of regenerative medicine. As economic considerations have shown, allogeneic therapy …

Scalable production of human mesenchymal stromal cell-derived extracellular vesicles under serum-/xeno-free conditions in a microcarrier-based bioreactor culture …

M de Almeida Fuzeta, N Bernardes… - Frontiers in Cell and …, 2020 - frontiersin.org
Mesenchymal stromal cells (MSC) hold great promise for tissue engineering and cell-based
therapies due to their multilineage differentiation potential and intrinsic immunomodulatory …

A review of fetal bovine serum in the culture of mesenchymal stromal cells and potential alternatives for veterinary medicine

CR Pilgrim, KA McCahill, JG Rops… - Frontiers in Veterinary …, 2022 - frontiersin.org
Fetal bovine serum (FBS) remains widely used as a supplement in cell culture media used
in the isolation and expansion of mesenchymal stromal cells (MSC) despite longstanding …

Translating mesenchymal stem cell and their exosome research into GMP compliant advanced therapy products: Promises, problems and prospects

CY Ma, Y Zhai, CT Li, J Liu, X Xu… - Medicinal Research …, 2024 - Wiley Online Library
Mesenchymal stem cells (MSCs) are one of the few stem cell types used in clinical practice
as therapeutic agents for immunomodulation and ischemic tissue repair, due to their unique …

Mesenchymal stromal cells: from discovery to manufacturing and commercialization

A Mizukami, K Swiech - Stem cells international, 2018 - Wiley Online Library
Over the last decades, mesenchymal stromal cells (MSC) have been the focus of intense
research by academia and industry due to their unique features. MSC can be easily isolated …

Bioprocessing strategies for the large-scale production of human mesenchymal stem cells: a review

KM Panchalingam, S Jung, L Rosenberg… - Stem cell research & …, 2015 - Springer
Human mesenchymal stem cells (hMSCs), also called mesenchymal stromal cells, have
been of great interest in regenerative medicine applications because of not only their …

Large‐scale expansion of human mesenchymal stem cells

MNFB Hassan, MD Yazid, MHM Yunus… - Stem Cells …, 2020 - Wiley Online Library
Mesenchymal stem cells (MSCs) are multipotent stem cells with strong immunosuppressive
property that renders them an attractive source of cells for cell therapy. MSCs have been …

Influence of microenvironment on mesenchymal stem cell therapeutic potency: from planar culture to microcarriers

AC Tsai, R Jeske, X Chen, X Yuan, Y Li - Frontiers in bioengineering …, 2020 - frontiersin.org
Human mesenchymal stem cells (hMSCs) are a promising candidate in cell therapy as they
exhibit multilineage differentiation, homing to the site of injury, and secretion of trophic …

[HTML][HTML] Process development for expansion of human mesenchymal stromal cells in a 50 L single-use stirred tank bioreactor

T Lawson, DE Kehoe, AC Schnitzler… - Biochemical …, 2017 - Elsevier
The application of cell-based therapeutics requires development of refined and scalable
culture processes. Stirred tank bioreactors facilitate growth of human mesenchymal stromal …