Fluid transport in the brain

MK Rasmussen, H Mestre… - Physiological …, 2022 - journals.physiology.org
The brain harbors a unique ability to, figuratively speaking, shift its gears. During
wakefulness, the brain is geared fully toward processing information and behaving, while …

The glymphatic system: a novel component of fundamental neurobiology

LM Hablitz, M Nedergaard - Journal of Neuroscience, 2021 - Soc Neuroscience
Throughout the body, lymphatic fluid movement supports critical functions including
clearance of excess fluid and metabolic waste. The glymphatic system is the analog of the …

The glymphatic system: Current understanding and modeling

T Bohr, PG Hjorth, SC Holst, S Hrabětová, V Kiviniemi… - IScience, 2022 - cell.com
We review theoretical and numerical models of the glymphatic system, which circulates
cerebrospinal fluid and interstitial fluid around the brain, facilitating solute transport. Models …

[HTML][HTML] The brain's glymphatic system: current controversies

H Mestre, Y Mori, M Nedergaard - Trends in neurosciences, 2020 - cell.com
The glymphatic concept along with the discovery of meningeal lymphatic vessels have, in
recent years, highlighted that fluid is directionally transported within the central nervous …

The glymphatic system: implications for drugs for central nervous system diseases

TJ Lohela, TO Lilius, M Nedergaard - Nature Reviews Drug Discovery, 2022 - nature.com
In the past decade, evidence for a fluid clearance pathway in the central nervous system
known as the glymphatic system has grown. According to the glymphatic system concept …

Cerebrospinal fluid flow

DH Kelley, JH Thomas - Annual Review of Fluid Mechanics, 2023 - annualreviews.org
Circulation of cerebrospinal fluid and interstitial fluid around the central nervous system and
through the brain transports not only those water-like fluids but also any solutes they carry …

The glymphatic system (en) during inflammation

FLH Mogensen, C Delle, M Nedergaard - International journal of …, 2021 - mdpi.com
The glymphatic system is a fluid-transport system that accesses all regions of the brain. It
facilitates the exchange of cerebrospinal fluid and interstitial fluid and clears waste from the …

The glymphatic hypothesis: the theory and the evidence

SB Hladky, MA Barrand - Fluids and Barriers of the CNS, 2022 - Springer
The glymphatic hypothesis proposes a mechanism for extravascular transport into and out of
the brain of hydrophilic solutes unable to cross the blood–brain barrier. It suggests that there …

A brief overview of the cerebrospinal fluid system and its implications for brain and spinal cord diseases

TO Wichmann, HH Damkier… - Frontiers in human …, 2022 - frontiersin.org
A comprehensive understanding of the cerebrospinal fluid (CSF) system is essential for our
understanding of health and disease within the central nervous system (CNS). The system of …

Artificial intelligence velocimetry reveals in vivo flow rates, pressure gradients, and shear stresses in murine perivascular flows

KAS Boster, S Cai… - Proceedings of the …, 2023 - National Acad Sciences
Quantifying the flow of cerebrospinal fluid (CSF) is crucial for understanding brain waste
clearance and nutrient delivery, as well as edema in pathological conditions such as stroke …