Pheochromocytomas are rare catecholamine-producing neuroendocrine tumors that are
usually benign, but which may also present as or develop into a malignancy. Predicting such …

Neuroblastoma stands out among pediatric solid tumors because of its relative frequency,
intriguing natural history, prognostic biologic features, and therapeutic challenges. It is the …

The optimal use and effectiveness of 131 I-meta iodobenzylguanidine (131 I-mIBG)
molecular radiotherapy for neuroblastoma remain unclear despite extensive clinical …

The norepinephrine transporter (NET) is essential for norepinephrine uptake at the synaptic
terminals and adrenal chromaffin cells. In neuroendocrine tumors, NET can be targeted for …

Purpose To report on an irinotecan and temozolomide regimen for neuroblastoma (NB).
Quality of life and minimizing toxicity were major considerations. Patients and Methods The …

Abstract 131 I-Metaiodobenzylguanidine (131 I-MIBG) has been used as a single agent or in
combination with chemotherapy for the treatment of high-risk neuroblastoma. The activity …

Disulfiram has been used for several decades in the treatment of alcoholism. It now shows
promise as an anticancer drug and radiosensitizer. Proposed mechanisms of action include …

Neuroblastoma is unique amongst common pediatric cancers for its expression of the
norepinephrine transporter (NET), enabling tumor‐selective imaging and therapy with …

More than half of the patients with high-risk neuroblastoma (NB) will relapse despite
intensive multimodal therapy, with an additional 10% to 20% refractory to induction …

INTRODUCTION: Neuroblastoma is the most common pediatric extracranial solid cancer.
This tumor is characterized by metaiodobenzylguanidine (MIBG) avidity in 90% of cases …