The biophysical modeling efforts in diffusion MRI have grown considerably over the past 25
years. In this review, we dwell on the various challenges along the journey of bringing a …

Quantitative diffusion imaging techniques enable the characterization of tissue
microstructural properties of the human brain “in vivo”, and are widely used in neuroscientific …

The spinal cord is frequently affected in multiple sclerosis (MS), causing motor, sensory and
autonomic dysfunction. A number of pathological abnormalities, including demyelination …

Multi-parametric quantitative MRI (qMRI) of the spinal cord is a promising non-invasive tool
to probe early microstructural damage in neurological disorders. It is usually performed in …

Clinicians involved with different aspects of the care of persons with multiple sclerosis (MS)
and scientists with expertise on clinical and imaging techniques convened in Dallas, TX …

Spinal cord disease is important in most people with multiple sclerosis, but assessment
remains less emphasized in patient care, basic and clinical research and therapeutic trials …

Conventional MR imaging techniques are sensitive to pathologic changes of the brain and
spinal cord seen in MS, but they lack specificity for underlying axonal and myelin integrity …

Spinal cord magnetic resonance imaging (MRI) has a central role in multiple sclerosis (MS)
clinical practice for diagnosis and disease monitoring. Advanced MRI sequences capable of …

Quantitative diffusion MRI (dMRI) is a promising technique for evaluating the spinal cord in
health and disease. However, low signal-to-noise ratio (SNR) can impede interpretation and …

Background: Neurite orientation dispersion and density imaging (NODDI) and the spherical
mean technique (SMT) are diffusion MRI methods providing metrics with sensitivity to similar …