Microglia are the resident innate immune cells in the brain with a major role in orchestrating
immune responses. They also provide a frontline of host defense in the central nervous …

Neurodegenerative diseases (NDs) are a class of heterogeneous diseases that includes
Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral …

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the world.
High levels of free fatty acids in the liver impair hepatic lysosomal acidification and reduce …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Lysosomal acidification dysfunction has been implicated as a key driving factor in the
pathogenesis of neurodegenerative diseases, including Alzheimer's disease and …

The discovery of effective drugs for the treatment of neurodegenerative disorders (NDs) is a
deadlock. Due to their complex etiology and high heterogeneity, progresses in the …

Although several nanomedicines got clinical approval over the past two decades, the clinical
translation rate is relatively small so far. There are many post-surveillance withdrawals of …

Biodegradable polymers are expected to be an alternative to plastics. Because of its high
biocompatibility, poly (lactic-co-glycolic acid)(PLGA) is widely used in medicine. It has been …

The incidence of tissue and organ damage caused by various diseases is increasing
worldwide. Tissue engineering is a promising strategy of tackling this problem because of its …

Treatment of neurodegenerative diseases has become one of the most challenging topics of
the last decades due to their prevalence and increasing societal cost. The crucial point of the …