▪ Abstract RNA viruses exploit all known mechanisms of genetic variation to ensure their
survival. Distinctive features of RNA virus replication include high mutation rates, high yields …

▪ Abstract Eukaryotic translation initiation factor 4F (eIF4F) is a protein complex that mediates
recruitment of ribosomes to mRNA. This event is the rate-limiting step for translation under …

The 5′ mRNA cap structure is essential for efficient gene expression from yeast to human. It
plays a critical role in all aspects of the life cycle of an mRNA molecule. Capping occurs co …

Abstract eIF4G uses a conserved Tyr-XXXX-Leu-φ segment (where X is variable and φ is
hydrophobic) to recognize eIF4E during cap-dependent translation initiation in eukaryotes …

Most eukaryotic mRNAs possess a 5′ cap and a 3′ poly (A) tail, both of which are
required for efficient translation. In yeast and plants, binding of eIF4G to poly (A)‐binding …

Eukaryotic initiation factor (elF) 4A functions as a subunit of the initiation factor complex
elF4F, which mediates the binding of mRNA to the ribosome. elF4A possesses ATPase and …

In positive-stranded viruses, the genomic RNA serves as a template for both translation and
RNA replication. Using poliovirus as a model, we examined the interaction between these …

Alan B. Sachs,* Peter Sarnow,† studies, which are covered in more detail below, these and
Matthias W. Hentze‡ current models fail to fully explain this early stage of* Department of …

Eukaryotic initiation factor (eIF) 4GI is a component of the cap-binding protein complex
eIF4F, which is required for cap-dependent translation. Infection of cells by poliovirus results …

As obligate intracellular parasites, viruses rely exclusively on the translational machinery of
the host cell for the synthesis of viral proteins. This relationship has imposed numerous …