Therapeutic cloning, whereby somatic cell nuclear transfer (SCNT) is used to generate
patient-specific embryonic stem cells (ESCs) from blastocysts cloned by nuclear transfer …

Proper response of normal stem cells (NSC) to motomorphogens and chemoattractants
plays a pivotal role in organ development and renewal/regeneration of damaged tissues …

Stem cells are self-renewing and undifferentiated cell types that can be differentiate into
functional cells. Stem cells can be classified into two main types based on their source of …

The Pou domain containing transcription factor Oct4 is a well-established regulator of
pluripotency in the inner cell mass of the mammalian blastocyst as well as in embryonic …

Oct4 is a key component of the pluripotency regulatory network, and its reciprocal interaction
with Cdx2 has been shown to be a determinant of either the self-renewal of embryonic stem …

Recently, we purified from adult murine bone marrow (BM) a population of CXCR4+, Oct-4+
SSEA-1+, Sca-1+ lin− CD45− very small embryonic-like (VSEL) stem cells and hypothesized …

It has been generally accepted for more than half a century that, in most mammalian
species, oocytes cannot renew themselves in postnatal or adult life, and that the number of …

Purpose Although early menopause frequently occurs in female cancer patients after
chemotherapy (CTx), bone marrow (BM) transplantation (BMT) has been linked to an …

A prerequisite to the understanding of the ovarian diseases and infertility is a thorough
understanding of normal embryology and physiology of the ovary. Therefore, the objective of …

Stem cells have been introduced as new promising therapeutic agents in treatment of
degenerative diseases because of having high differentiation potential while maintaining the …