Several software tools are available that facilitate the use of the NONMEM software and
extend its functionality. This tutorial shows how three commonly used and freely available …

Children differ from adults in their response to drugs. While this may be the result of changes
in dose exposure (pharmacokinetics [PK]) and/or exposure response (pharmacodynamics …

Population pharmacokinetic models are used to describe the time course of drug exposure
in patients and to investigate sources of variability in patient exposure. They can be used to …

This article represents the first in a series of tutorials on model evaluation in nonlinear mixed
effect models (NLMEMs), from the International Society of Pharmacometrics (ISoP) Model …

Abstract Empirical Bayes (“post hoc”) estimates (EBEs) of ηs provide modelers with
diagnostics: the EBEs themselves, individual prediction (IPRED), and residual errors …

Pharmacokinetic/pharmacodynamic data are often analysed using nonlinear mixed-effect
models, and model evaluation should be an important part of the analysis. Recently …

In this second tutorial on NONMEM, the examples of typical pharmacokinetic/
pharmacodynamic modeling problems that occur in the pharmaceutical field will be …

The pharmacokinetics of miltefosine in leishmaniasis patients are, to a great extent,
unknown. We examined and characterized the pharmacokinetics of miltefosine in a group of …

Abstract Background and Objective Metformin is contraindicated in patients with renal
impairment; however, there is poor adherence to current dosing guidelines. In addition, the …

Linezolid is an antimicrobial agent to treat infections by Gram-positive pathogens, including
methicillin-resistant Staphylococcus aureus (MRSA). While effective, linezolid treatment …