The roles of serotonin in neuropsychiatric disorders

M Pourhamzeh, FG Moravej, M Arabi… - Cellular and molecular …, 2022 - Springer
The serotonergic system extends throughout the central nervous system (CNS) and the
gastrointestinal (GI) tract. In the CNS, serotonin (5-HT, 5-hydroxytryptamine) modulates a …

Seasonality of brain function: role in psychiatric disorders

R Zhang, ND Volkow - Translational Psychiatry, 2023 - nature.com
Seasonality patterns are reported in various psychiatric disorders. The current paper
summarizes findings on brain adaptations associated with seasonal changes, factors that …

Melatonin ameliorates cognitive deficits through improving mitophagy in a mouse model of Alzheimer's disease

C Chen, C Yang, J Wang, X Huang… - Journal of Pineal …, 2021 - Wiley Online Library
While melatonin is known to have protective effects in mitochondria‐related diseases, aging,
and neurodegenerative disorders, there is poor understanding of the effects of melatonin …

The serotonergic system and cognitive function

D Švob Štrac, N Pivac, D Mück-Šeler - Translational neuroscience, 2016 - degruyter.com
Symptoms of cognitive dysfunction like memory loss, poor concentration, impaired learning
and executive functions are characteristic features of both schizophrenia and Alzheimer's …

The gut-brain axis, the human gut microbiota and their integration in the development of obesity

ES Bliss, E Whiteside - Frontiers in physiology, 2018 - frontiersin.org
Obesity is a global epidemic, placing socioeconomic strain on public healthcare systems,
especially within the so-called Western countries, such as Australia, United States, United …

New therapeutics beyond amyloid-β and tau for the treatment of Alzheimer's disease

F Zhang, R Zhong, C Cheng, S Li, W Le - Acta Pharmacologica Sinica, 2021 - nature.com
As the population ages, Alzheimer's disease (AD), the most common neurodegenerative
disease in elderly people, will impose social and economic burdens to the world. Currently …

Pharmacological targeting of cognitive impairment in depression: recent developments and challenges in human clinical research

MJ Colwell, H Tagomori, S Chapman… - Translational …, 2022 - nature.com
Impaired cognition is often overlooked in the clinical management of depression, despite its
association with poor psychosocial functioning and reduced clinical engagement. There is …

Serotonergic system, cognition, and BPSD in Alzheimer's disease

S Chakraborty, JC Lennon, SA Malkaram, Y Zeng… - Neuroscience …, 2019 - Elsevier
Abstract Behavioral and Psychological Symptoms of Dementia (BPSD), present in almost
90% of patients with Alzheimer's Disease (AD), cause extensive impairment leading to …

Structure, dynamics and lipid interactions of serotonin receptors: excitements and challenges

P Sarkar, S Mozumder, A Bej, S Mukherjee… - Biophysical …, 2021 - Springer
Abstract Serotonin (5-hydroxytryptamine, 5-HT) is an intrinsically fluorescent
neurotransmitter found in organisms spanning a wide evolutionary range. Serotonin exerts …

Transdiagnostic neurocognitive deficits in psychiatry: A review of meta-analyses.

C East-Richard, A R-Mercier, D Nadeau… - Canadian Psychology …, 2020 - psycnet.apa.org
Plusieurs méta-analyses documentant l'impact des troubles psychiatriques sur le
fonctionnement neuropsychologique ont été publiées. Le premier objectif de cette recension …