Background Researchers now have a new avenue to investigate when it comes to miRNA-
based therapeutics. miRNAs have the potential to be valuable biomarkers for disease …

Common environmental pollutants and drugs encountered in everyday life can cause toxic
damage to the body through oxidative stress, inflammatory stimulation, induction of …

Sirtuins are evolutionarily conserved protein, serving as nicotinamide adenine dinucleotide-
dependent deacetylases or adenosine diphosphate-ribosyltransferases. The mammalian …

To date, natural products are widely used as pharmaceutical agents for many human
diseases and cancers. One of the most popular natural products that have been studied for …

Aims This study aimed to investigate the effects of resveratrol (3, 4′, 5-trihydroxystilbene,
RES) on osteoporosis and the role of SIRT1/FoxO1 pathway in the process. Main methods In …

NAD+-dependent deacetylase sirtuin-1 (Sirt1) belongs to the sirtuins family, known to be
longevity regulators, and exerts a key role in the prevention of vascular aging. By aging, the …

Dynamic aspects of melatonin's actions merit increasing future attention. This concerns
particularly entirely different effects in senescent, weakened oscillators and in dysregulated …

Cancer is one of the most complicated diseases in present-day medical science. Yearly,
several studies suggest various strategies for preventing carcinogenesis. Furthermore …

Nicotinamide adenine dinucleotide (NAD+) metabolism plays a critical role in kidneys. We
previously reported that decreased secretion of a NAD+ precursor, nicotinamide …

Sirtuins participate in hormone imbalance, metabolism and aging, which are important
processes for endometrial cancer (EC) development. Sirtuins mRNA expression (SIRT1 to 7) …