The resurgence of interest in anhedonia within major depression has been fuelled by
clinical trials demonstrating its utility in predicting antidepressant response as well as recent …

Anhedonia is one of the core symptoms of major depressive disorder (MDD), which is often
inadequately treated by traditional antidepressants. The modern framework of anhedonia …

Importance Delay discounting is a behavioral economic index of impulsive preferences for
smaller-immediate or larger-delayed rewards that is argued to be a transdiagnostic process …

Impulsive behavior is a core DSM-5 diagnostic feature of attention-deficit/hyperactivity
disorder (ADHD) that is associated with several pejorative outcomes. Impulsivity is …

Balancing behaviors that provide a reward NOW versus behaviors that provide an
advantage LATER is critical for survival. We propose a model in which dopamine (DA) can …

Slow response to the standard treatment for depression increases suffering and risk of
suicide. Ketamine, an N-methyl-d-aspartate (NMDA) receptor antagonist, can rapidly …

Two seemingly associated demographic trends have generated considerable interest:
income stagnation and rising premature mortality from suicides, drug poisoning, and …

Ancestral experiences and evolutionary processes continue to influence the brain in ways
that may escape conscious awareness by contemporary adults. It is becoming increasingly …

Patch foraging presents a sequential decision-making problem widely studied across
organisms—stay with a current option or leave it in search of a better alternative? Behavioral …

In 21st-century public health, rapid urbanization and mental health disorders are a growing
global concern. The relationship between diet, brain function and the risk of mental …