The regulation of cartilage extracellular matrix homeostasis in joint cartilage degeneration and regeneration

Z Peng, H Sun, V Bunpetch, Y Koh, Y Wen, D Wu… - Biomaterials, 2021 - Elsevier
Osteoarthritis (OA) is a major cause of disability and socioeconomic loss worldwide.
However, the current pharmacological approaches used to treat OA are largely palliative …

Regulatory effects and interactions of the Wnt and OPG-RANKL-RANK signaling at the bone-cartilage interface in osteoarthritis

B Kovács, E Vajda, EE Nagy - International journal of molecular sciences, 2019 - mdpi.com
Cartilage and the bordering subchondral bone form a functionally active regulatory interface
with a prominent role in osteoarthritis pathways. The Wnt and the OPG-RANKL-RANK …

Prevalence trends of site‐specific osteoarthritis from 1990 to 2019: findings from the global burden of disease study 2019

H Long, Q Liu, H Yin, K Wang, N Diao… - Arthritis & …, 2022 - Wiley Online Library
Objective To estimate systematic and anatomic site–specific age‐standardized prevalence
rates (ASRs) and analyze the secular trends of osteoarthritis (OA) at global, regional, and …

Early osteoarthritis of the knee

H Madry, E Kon, V Condello, GM Peretti… - Knee Surgery, Sports …, 2016 - Springer
There is an increasing awareness on the importance in identifying early phases of the
degenerative processes in knee osteoarthritis (OA), the crucial period of the disease when …

An updated knowledge of Black seed (Nigella sativa Linn.): Review of phytochemical constituents and pharmacological properties

MF Ahmad, FA Ahmad, SA Ashraf, HH Saad… - Journal of herbal …, 2021 - Elsevier
Abstract N. sativa (N. sativa) has been used since ancient times, when a scientific concept
about the use of medicinal plants for the treatment of human illnesses and alleviation of their …

[HTML][HTML] An educational review of cartilage repair: precepts & practice–myths & misconceptions–progress & prospects

EB Hunziker, K Lippuner, MJB Keel… - Osteoarthritis and …, 2015 - Elsevier
Objective The repair of cartilaginous lesions within synovial joints is still an unresolved and
weighty clinical problem. Although research activity in this area has been indefatigably …

[HTML][HTML] In vitro models for the study of osteoarthritis

CI Johnson, DJ Argyle, DN Clements - The Veterinary Journal, 2016 - Elsevier
Osteoarthritis (OA) is a prevalent disease of most mammalian species and is a significant
cause of welfare and economic morbidity in affected individuals and populations. In vitro …

Early knee osteoarthritis

M Favero, R Ramonda, MB Goldring, SR Goldring… - RMD open, 2015 - rmdopen.bmj.com
Concepts regarding osteoarthritis, the most common joint disease, have dramatically
changed in the past decade thanks to the development of new imaging techniques and the …

The infrapatellar fat pad and the synovial membrane: an anatomo‐functional unit

V Macchi, E Stocco, C Stecco, E Belluzzi… - Journal of …, 2018 - Wiley Online Library
The infrapatellar pad, a fibro‐adipose tissue with peculiar microscopic and mechanical
features, is gaining wide attention in the field of rheumatological research. The purpose of …

Osteoarthritis: novel molecular mechanisms increase our understanding of the disease pathology

S Grässel, F Zaucke, H Madry - Journal of clinical medicine, 2021 - mdpi.com
Although osteoarthritis (OA) is the most common musculoskeletal condition that causes
significant health and social problems worldwide, its exact etiology is still unclear. With an …