Sheep and goat genome engineering: from random transgenesis to the CRISPR era

P Kalds, S Zhou, B Cai, J Liu, Y Wang… - Frontiers in …, 2019 - frontiersin.org
Sheep and goats are valuable livestock species that have been raised for their production of
meat, milk, fiber, and other by-products. Due to their suitable size, short gestation period …

When Less Is More: Targeting the Myostatin Gene in Livestock for Augmenting Meat Production

P Kalds, S Zhou, S Huang, Y Gao… - Journal of Agricultural …, 2023 - ACS Publications
How to increase meat production is one of the main questions in animal breeding. Selection
for improved body weight has been made and, due to recent genomic advances, naturally …

miR-181b-5p may regulate muscle growth in tilapia by targeting myostatin b

Z Zhao, X Yu, J Jia, G Yang, C Sun, W Li - Frontiers in endocrinology, 2019 - frontiersin.org
Background: Myostatin (Mstn), a member of the TGF-β superfamily, is a negative regulator of
skeletal muscle mass in mammals. Precise regulation of Mstn expression is important for …

Myostatin knockdown and its effect on myogenic gene expression program in stably transfected goat myoblasts

AK Patel, AK Tripathi, UA Patel, RK Shah… - In Vitro Cellular & …, 2014 - Springer
Myostatin, a negative regulator of skeletal muscle mass, is a proven candidate to modulate
skeletal muscle mass through targeted gene knockdown approach. Here, we report …

Short-hairpin mediated myostatin knockdown resulted in altered expression of myogenic regulatory factors with enhanced myoblast proliferation in fetal myoblast cells …

R Kumar, SP Singh, A Mitra - Animal biotechnology, 2018 - Taylor & Francis
Myostatin (MSTN) is a well-known negative regulator of skeletal muscle development.
Reduced expression due to natural mutations in the coding region and knockout as well as …

[HTML][HTML] 干扰MSTN对绵羊成肌细胞增殖分化及相关基因表达的影响

王红娜, 孙洪新, 张英杰, 刘月琴, 谷振慧, 史秀芬 - 畜牧兽医学报, 2018 - xml-data.org
旨在探讨MSTN 基因对绵羊成肌细胞增殖和分化的作用及相关机制, 进一步揭示MSTN
在绵羊成肌细胞中的生物学功能. 本研究利用重组腺病毒介导shRNA 干扰绵羊成肌细胞内源性 …

Production of Transgenic Chimeric Chicken from Cryopreserved Primordial Germ Cells and its Validation by Developing shRNA Transgenic Chicken Chimera

D Divya, R Shukla, RN Chatterjee, G Sagar, AR Prasad… - 2021 - researchsquare.com
Primordial germ cells (PGCs) are precursors of gametes in birds. For ex-situ conservation
and production of transgenic birds, there is a limitation for preservation of oocytes in birds as …

Myostatin (GDF8) gene and its intriguing role in regulating growth in poultry

TK Bhattacharya, BR Reddy… - The Indian Journal of …, 2022 - epubs.icar.org.in
Myostatin, also called as growth differentiating factor 8 (GDF8), a negative regulator of
growth in chicken has been characterized at nucleotide and protein level. The total length of …

斜带石斑鱼mstn 对其肌肉细胞增殖分化及相关基因表达的影响.

杨炎, 夏俊, 王庆, 何颖琳, 张勇… - Acta Scientiarum …, 2022 - search.ebscohost.com
斜带石斑鱼Epinephelus coioides 是具有较高经济价值的海水鱼, 如何促进石斑鱼生产性状改良
一直是科学研究的重点之一. 肌肉生长抑制素(mstn, myostatin) 是调节肌肉生长的重要转化因子 …

[HTML][HTML] 腺病毒介导shRNA干扰绵羊MSTN基因效果及对生肌调节因子和干扰素反应基因表达的影响

王红娜, 孙洪新, 张英杰, 刘月琴, 谷振慧, 王苏瑶 - 畜牧兽医学报, 2017 - xml-data.org
旨在进一步揭示MSTN 在绵羊成肌细胞中的调控机制, 制备可有效失活MSTN 基因的工具,
为通过RNA 干扰技术提高绵羊产肉量提供方法和理论依据. 本研究以绵羊成肌细胞为试验材料 …