Generally, heterocycles occupy a prominent place in chemistry due to their wide range of
applications in the fields of drug design, photochemistry, agrochemicals, dyes and so on …

The indole scaffold is one of the most widespread heterocycles in the naturally occurring
and synthetic bioactive compounds including anticancer agents. Due to its biodiversity and …

Drug efflux pumps play a key role in drug resistance and also serve other functions in
bacteria. There has been a growing list of multidrug and drug-specific efflux pumps …

Heterocycles are an extraordinarily important class of compounds, making up more than half
of all known organic compounds. Heterocycles are present in a wide variety of drugs, most …

Bacterial infections are an increasingly serious issue worldwide. The inability of existing
therapies to treat multidrug‐resistant pathogens has been recognized as an important …

The rapid spread of bacteria expressing multidrug resistance (MDR) has necessitated the
discovery of new antibacterials and resistance-modifying agents. Since the initial discovery …

Antibacterial-resistance speaks to an overall alarm, particularly in regards to the flare-up of
methicillin-resistance Staphylococcus aureus (MRSA), a classic reason for genuine skin and …

Infectious diseases continue to be one of the major contributors to human morbidity. The
rapid rate at which pathogenic microorganisms have developed resistance against frontline …

The paper focuses on recent achievements in the search for new chemical compounds able
to inhibit multidrug resistance (MDR) mechanisms in Gram-positive pathogens. An analysis …

Background Traditional antibiotics are increasingly suffering from the emergence of
multidrug resistance amongst pathogenic bacteria leading to a range of novel approaches to …