This review is focused on purinergic neurotransmission, ie, ATP released from nerves as a
transmitter or cotransmitter to act as an extracellular signaling molecule on both pre-and …

Calcium signaling is critical to neuronal function and regulates highly diverse processes
such as gene transcription, energy production, protein handling, and synaptic structure and …

Background The purinergic receptor P2x7 is expressed on myeloid cells as well as on CNS
glial cells, and P2x7 activation has been shown to increase both glial and T-cell activation …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by a progressive
loss of memory and cognitive ability and is a serious cause of mortality. Many of the …

The P2RX7 receptor is a unique member of a family of extracellular ATP (eATP)-gated ion
channels expressed in immune cells, where its activation triggers the inflammatory cascade …

Potent actions of ATP in the central nervous system (CNS) were reported in the late 1940's,
but cloning and characterisation of receptors for purines and pyrimidines did not take place …

Extracellular purines and pyrimidines play major roles during embryogenesis,
organogenesis, postnatal development and ageing in vertebrates, including humans …

The purinergic receptor P2X7 is expressed in neural and immune cells known to be involved
in neurological diseases. Its ligand, ATP, is a signaling molecule that can act as a …

In addition to short-term effects, one of the fundamental roles of extracellular nucleotides in
the central nervous system involves long-term trophic effects. Physiological outcomes …

Stressed cells release ATP, which participates in neurodegenerative processes through the
specific ligation of P2RX7 purinergic receptors. Here, we demonstrate that extracellular ATP …