Current models for the folding of the human genome see a hierarchy stretching down from
chromosome territories, through A/B compartments and topologically-associating domains …

The highly reproducible inheritance of chromosomes during mitosis in mammalian cells
involves nuclear envelope breakdown, increased chromatin compaction, loss of long-range …

Although the genome is generally thought to be transcriptionally silent during mitosis,
technical limitations have prevented sensitive mapping of transcription during mitosis and …

Quantitative mass spectrometry has established proteome-wide regulation of protein
abundance and post-translational modifications in various biological processes. Here, we …

G-quadruplexes (G4s) are noncanonical DNA secondary structures formed through the self-
association of guanines, and G4s are distributed widely across the genome. G4 participates …

It is currently assumed that 3D chromosomal organization plays a central role in
transcriptional control. However, depletion of cohesin and CTCF affects the steady-state …

Transcription initiation entails chromatin opening followed by pre-initiation complex
formation and RNA polymerase II recruitment. Subsequent polymerase elongation requires …

Widespread antisense long noncoding RNA (lncRNA) overlap with many protein-coding
genes in mammals and emanate from gene promoter, enhancer, and termination regions …

During self-renewal, cell-type-defining features are drastically perturbed in mitosis and must
be faithfully reestablished upon G1 entry, a process that remains largely elusive. Here, we …

An R loop is a unique triple-stranded structure that participates in multiple key biological
processes and is relevant to human diseases. Accurate and comprehensive R loop profiling …