Abstract SN38 (7-ethyl-10-hydroxy camptothecin) is a prominent and efficacious anticancer
agent. It is poorly soluble in both water and pharmaceutically approved solvents; therefore …

Camptothecins (CPTs) are cytotoxic natural alkaloids that specifically target DNA
topoisomerase I. Research on CPTs has undergone a significant evolution from the initial …

A tremendous interest exists in the Western world in Traditional Chinese Medicine (TCM)
with rapidly increasing export rates of TCM products from China to Europe and USA. This …

Pyrazine is a six-membered heterocyclic ring containing nitrogen, and many of its
derivatives are biologically active compounds. References have been downloaded through …

This chapter gives an overview of methods for the synthesis of NH-and N (2)-substituted 1, 2,
3-triazoles, their advantages, lacks, scope, and limitations. Moreover, it will give some …

Camptothecin (CPT), obtained from Camptotheca acuminata (Nyssaceae), is a quinoline
type of alkaloid. Apart from various traditional uses, it is mainly used as a potential cytotoxic …

A series of novel indolylquinones have been synthesized by treating halogeno-quinone with
2-substituated indole derivatives in the presence of kalium carbonate and TEBA in …

Camptothecin-20 (s)-O-(2-pyrazolyl-1) acetic ester (CPT6) is a novel semi-synthetic analog
of camptothecin. In a previous report, CPT6 possessed higher cytotoxic activity in vitro …

Deletion of phenylalanine residue 508 (ΔF508) in the cystic fibrosis (CF) transmembrane
conductance regulator protein (CFTR) is a major cause of CF. Small molecule “correctors” of …

A new drug carrier system based on self-assembly and polymerization of polydiacetylenic
amphiphiles is described. Although classical amphiphiles can help in solubilizing …