Age‐associated diseases are rising to pandemic proportions, exposing the need for efficient
and low‐cost methods to tackle these maladies at symptomatic, behavioral, metabolic, and …

Fasting has been practiced for millennia, but, only recently, studies have shed light on its
role in adaptive cellular responses that reduce oxidative damage and inflammation, optimize …

Background The appropriate caloric goal for critically ill adults is unclear. We evaluated the
effect of restriction of nonprotein calories (permissive underfeeding), as compared with …

Background Acute kidney injury (AKI) in the intensive care unit is associated with significant
mortality and morbidity. Objectives To determine and update previous recommendations for …

Background For several decades, intermediate metabolism and signal transduction have
been considered two independent entities. On one side stood the catabolic and anabolic …

Dietary restriction (DR) without malnutrition encompasses numerous regimens with
overlapping benefits including longevity and stress resistance, but unifying nutritional and …

Short-term starvation (or fasting) protects normal cells, mice, and potentially humans from
the harmful side effects of a variety of chemotherapy drugs. Here, we show that treatment …

Ischemia-reperfusion injury is an important cause of liver damage occurring during surgical
procedures including hepatic resection and liver transplantation, and represents the main …

Evolution favored individuals with superior cognitive and physical abilities under conditions
of limited food sources, and brain function can therefore be optimized by intermittent dietary …

The dietary recommendation for cancer patients receiving chemotherapy, as described by
the American Cancer Society, is to increase calorie and protein intake. Yet, in simple …