Stem-cell therapy for bronchopulmonary dysplasia (BPD) in newborns

SA Omar, A Abdul-Hafez, S Ibrahim, N Pillai… - Cells, 2022 - mdpi.com
Premature newborns are at a higher risk for the development of respiratory distress
syndrome (RDS), acute lung injury (ALI) associated with lung inflammation, disruption of …

Advances in neonatal cell therapies: proceedings of the First Neonatal Cell Therapies Symposium (2022)

A Malhotra, B Thebaud, MCB Paton, B Fleiss… - Pediatric …, 2023 - nature.com
Despite considerable advances, there is a need to improve the outcomes of newborn
infants, especially related to prematurity, encephalopathy and other conditions. In principle …

[PDF][PDF] Neoantigen‐based cancer vaccination using chimeric RNA‐loaded dendritic cell‐derived extracellular vesicles

X Xiong, X Ke, L Wang, Y Lin, S Wang… - Journal of …, 2022 - Wiley Online Library
Cancer vaccines critically rely on the availability of targetable immunogenic cancer‐specific
neoepitopes. However, mutation‐based immunogenic neoantigens are rare or even non …

When inflammation meets lung development—an update on the pathogenesis of bronchopulmonary dysplasia

L Holzfurtner, T Shahzad, Y Dong, L Rekers… - Molecular and cellular …, 2022 - Springer
Even more than 50 years after its initial description, bronchopulmonary dysplasia (BPD)
remains one of the most important and lifelong sequelae following premature birth …

Peritoneal M2 macrophage-derived extracellular vesicles as natural multitarget nanotherapeutics to attenuate cytokine storms after severe infections

Y Wang, S Liu, L Li, L Li, X Zhou, M Wan, P Lou… - Journal of Controlled …, 2022 - Elsevier
Cytokine storms are a primary cause of multiple organ damage and death after severe
infections, such as SARS-CoV-2. However, current single cytokine-targeted strategies …

Mesenchymal stem cell-derived extracellular vesicles prevent experimental bronchopulmonary dysplasia complicated by pulmonary hypertension

M Sharma, MA Bellio, M Benny… - Stem cells …, 2022 - academic.oup.com
Mesenchymal stem cell (MSC) extracellular vesicles (EVs) have beneficial effects in
preclinical bronchopulmonary dysplasia and pulmonary hypertension (BPD-PH) models …

Diagnosis and management of pulmonary hypertension in infants with bronchopulmonary dysplasia

PT Levy, J Levin, KT Leeman, MP Mullen… - Seminars in Fetal and …, 2022 - Elsevier
Chronic pulmonary hypertension of infancy (cPHi) is a heterogeneous disease process that
contributes to morbidity and mortality in preterm infants. cPHi is most commonly associated …

Harnessing the therapeutic potential of the stem cell secretome in neonatal diseases

S Tung, E Delavogia, A Fernandez-Gonzalez… - Seminars in …, 2023 - Elsevier
Preterm birth and intrapartum related complications account for a substantial amount of
mortality and morbidity in the neonatal period despite significant advancements in neonatal …

Extracellular vesicles in corneal fibrosis/scarring

V Yeung, N Boychev, W Farhat, DP Ntentakis… - International Journal of …, 2022 - mdpi.com
Communication between cells and the microenvironment is a complex, yet crucial, element
in the development and progression of varied physiological and pathological processes …

Human Amniotic Fluid Mesenchymal Stem Cell‐Derived Exosomes Inhibit Apoptosis in Ovarian Granulosa Cell via miR‐369‐3p/YAF2/PDCD5/p53 Pathway

Z Geng, H Chen, G Zou, L Yuan, P Liu… - Oxidative medicine …, 2022 - Wiley Online Library
Human amniotic fluid stem cell‐derived exosome (HuAFSC‐exosome) transplantation is
considered a promising treatment for premature ovarian failure (POF). However, its …