[HTML][HTML] A general exposome factor explains individual differences in functional brain network topography and cognition in youth
Childhood environments are critical in shaping cognitive neurodevelopment. With the
increasing availability of large-scale neuroimaging datasets with deep phenotyping of …
increasing availability of large-scale neuroimaging datasets with deep phenotyping of …
Large Language Model-Based Natural Language Encoding Could Be All You Need for Drug Biomedical Association Prediction
Analyzing drug-related interactions in the field of biomedicine has been a critical aspect of
drug discovery and development. While various artificial intelligence (AI)-based tools have …
drug discovery and development. While various artificial intelligence (AI)-based tools have …
Hierarchical individual variation and socioeconomic impact on personalized functional network topography in children
Background The spatial layout of large-scale functional brain networks exhibits considerable
inter-individual variability, especially in the association cortex. Research has demonstrated …
inter-individual variability, especially in the association cortex. Research has demonstrated …
[HTML][HTML] The connecting brain in context: How adolescent plasticity supports learning and development
Puberty initiates significant neurobiological changes that amplify adolescents'
responsiveness to their environment, facilitating neural adaptation through processes like …
responsiveness to their environment, facilitating neural adaptation through processes like …
Individual brain parcellation: Review of methods, validations and applications
Individual brains vary greatly in morphology, connectivity and organization. The applicability
of group-level parcellations is limited by the rapid development of precision medicine today …
of group-level parcellations is limited by the rapid development of precision medicine today …
[HTML][HTML] Reconfiguration of functional brain network organization and dynamics with changing cognitive demands in children with attention-deficit/hyperactivity …
C Michael, ME Mitchell, AD Cascone… - Biological Psychiatry …, 2024 - Elsevier
Background The pathophysiology of attention-deficit/hyperactivity disorder (ADHD) is
characterized by atypical brain network organization and dynamics. Although functional …
characterized by atypical brain network organization and dynamics. Although functional …
Precision functional mapping for target engagement in drug development
JS Siegel - 2024 - nature.com
Biomarkers are critical for advancing the development of experimental CNS therapeutics.
Efforts to identify reliable drug biomarkers using resting and task fMRI have been …
Efforts to identify reliable drug biomarkers using resting and task fMRI have been …
Personalized Single-cell Transcriptomics Reveals Molecular Diversity in Alzheimer's Disease
Precision medicine for brain diseases faces many challenges, including understanding the
heterogeneity of disease phenotypes. Such heterogeneity can be attributed to the variations …
heterogeneity of disease phenotypes. Such heterogeneity can be attributed to the variations …
[HTML][HTML] pNet: A toolbox for personalized functional networks modeling
Personalized functional networks (FNs) derived from functional magnetic resonance
imaging (fMRI) data are useful for characterizing individual variations in the brain functional …
imaging (fMRI) data are useful for characterizing individual variations in the brain functional …
[HTML][HTML] Polygenic Risk Underlies Youth Psychopathology and Personalized Functional Brain Network Topography
Importance: Functional brain networks are associated with both behavior and genetic
factors. To uncover clinically translatable mechanisms of psychopathology, it is critical to …
factors. To uncover clinically translatable mechanisms of psychopathology, it is critical to …