COVID-19 convalescent plasma and clinical trials: understanding conflicting outcomes

D Focosi, M Franchini, L Pirofski… - Clinical microbiology …, 2022 - Am Soc Microbiol
Convalescent plasma (CP) recurs as a frontline treatment in epidemics because it is
available as soon as there are survivors. The COVID-19 pandemic represented the first …

Guidance on the use of convalescent plasma to treat immunocompromised patients with coronavirus disease 2019

EM Bloch, D Focosi, S Shoham… - Clinical Infectious …, 2023 - academic.oup.com
Abstract Coronavirus disease 2019 (COVID-19) convalescent plasma (CCP) is a safe and
effective treatment for COVID-19 in immunocompromised (IC) patients. IC patients have a …

Early outpatient treatment for Covid-19 with convalescent plasma

DJ Sullivan, KA Gebo, S Shoham… - … England Journal of …, 2022 - Mass Medical Soc
Background Polyclonal convalescent plasma may be obtained from donors who have
recovered from coronavirus disease 2019 (Covid-19). The efficacy of this plasma in …

High-titre methylene blue-treated convalescent plasma as an early treatment for outpatients with COVID-19: a randomised, placebo-controlled trial

A Alemany, P Millat-Martinez… - The Lancet …, 2022 - thelancet.com
Background Convalescent plasma has been proposed as an early treatment to interrupt the
progression of early COVID-19 to severe disease, but there is little definitive evidence. We …

Efficacy and safety of COVID-19 convalescent plasma in hospitalized patients: a randomized clinical trial

MB Ortigoza, H Yoon, KS Goldfeld… - JAMA internal …, 2022 - jamanetwork.com
Importance There is clinical equipoise for COVID-19 convalescent plasma (CCP) use in
patients hospitalized with COVID-19. Objective To determine the safety and efficacy of CCP …

Stratification of hospitalized COVID-19 patients into clinical severity progression groups by immuno-phenotyping and machine learning

YM Mueller, TJ Schrama, R Ruijten… - Nature …, 2022 - nature.com
Quantitative or qualitative differences in immunity may drive clinical severity in COVID-19.
Although longitudinal studies to record the course of immunological changes are ample …

Convalescent plasma associates with reduced mortality and improved clinical trajectory in patients hospitalized with COVID-19

SAA Egloff, A Junglen, JSA Restivo… - The Journal of …, 2021 - Am Soc Clin Investig
BACKGROUND Evidence supporting convalescent plasma (CP), one of the first
investigational treatments for coronavirus disease 2019 (COVID-19), has been inconclusive …

[HTML][HTML] Rates among hospitalized patients with COVID-19 treated with convalescent plasma: a systematic review and meta-analysis

JW Senefeld, EK Gorman, PW Johnson, ME Moir… - … : Innovations, Quality & …, 2023 - Elsevier
Objective To examine the association of COVID-19 convalescent plasma transfusion with
mortality and the differences between subgroups in hospitalized patients with COVID-19 …

Estimates of actual and potential lives saved in the United States from the use of COVID-19 convalescent plasma

Q Dragotakes, PW Johnson, MR Buras… - Proceedings of the …, 2024 - pnas.org
In the Spring of 2020, the United States of America (USA) deployed COVID-19 convalescent
plasma (CCP) to treat hospitalized patients. Over 500,000 patients were treated with CCP …

Convalescent plasma therapy for COVID-19: a graphical mosaic of the worldwide evidence

SA Klassen, JW Senefeld, KA Senese… - Frontiers in …, 2021 - frontiersin.org
Convalescent plasma has been used worldwide to treat patients hospitalized with
coronavirus disease 2019 (COVID-19) and prevent disease progression. Despite global …