Ion channels as therapeutic antibody targets
CJ Hutchings, P Colussi, TG Clark - MAbs, 2019 - Taylor & Francis
It is now well established that antibodies have numerous potential benefits when developed
as therapeutics. Here, we evaluate the technical challenges of raising antibodies to …
as therapeutics. Here, we evaluate the technical challenges of raising antibodies to …
Distinction of early complement classical and lectin pathway activation via quantification of C1s/C1-INH and MASP-1/C1-INH complexes using novel ELISAs
L Hurler, EJM Toonen, E Kajdácsi, B van Bree… - Frontiers in …, 2022 - frontiersin.org
The most commonly used markers to assess complement activation are split products that
are produced through activation of all three pathways and are located downstream of C3. In …
are produced through activation of all three pathways and are located downstream of C3. In …
A novel monoclonal antibody reveals the enrichment of NADPH oxidase 5 in human splenic endothelial cells
Members of the NOX/DUOX family of NADPH oxidases are responsible for regulated ROS
production in diverse cells and tissues. Detection of NOX/DUOX proteins at the protein level …
production in diverse cells and tissues. Detection of NOX/DUOX proteins at the protein level …
Strategies for generating diverse antibody repertoires using transgenic animals expressing human antibodies
WC Chen, CM Murawsky - Frontiers in immunology, 2018 - frontiersin.org
Therapeutic molecules derived from antibodies have become a dominant class of drugs
used to treat human disease. Increasingly, therapeutic antibodies are discovered using …
used to treat human disease. Increasingly, therapeutic antibodies are discovered using …
Accelerating antibody discovery using transgenic animals overexpressing the neonatal Fc receptor as a result of augmented humoral immunity
J Cervenak, R Kurrle, I Kacskovics - Immunological reviews, 2015 - Wiley Online Library
In recent years, there has been an increasing demand for the development of faster and
more efficient technologies for the generation of monoclonal antibodies against challenging …
more efficient technologies for the generation of monoclonal antibodies against challenging …
Over‐expression of the bovine FcRn in the mammary gland results in increased IgG levels in both milk and serum of transgenic mice
W Lu, Z Zhao, Y Zhao, S Yu, Y Zhao, B Fan… - …, 2007 - Wiley Online Library
Summary The neonatal Fc receptor (FcRn) protects immunoglobulin G (IgG) from catabolism
and is also responsible for IgG absorption in the neonatal small intestine. However, whether …
and is also responsible for IgG absorption in the neonatal small intestine. However, whether …
TGEV infection up-regulates FcRn expression via activation of NF-κB signaling
J Guo, F Li, S Qian, D Bi, Q He, H Jin, R Luo, S Li… - Scientific reports, 2016 - nature.com
It has been well characterized that the neonatal Fc receptor (FcRn) transports maternal IgG
to a fetus or newborn and protects IgG from degradation. We previously reported that FcRn …
to a fetus or newborn and protects IgG from degradation. We previously reported that FcRn …
Characterization of the rabbit neonatal Fc receptor (FcRn) and analyzing the immunophenotype of the transgenic rabbits that overexpresses FcRn
AP Catunda Lemos, J Cervenak, B Bender… - PloS one, 2012 - journals.plos.org
The neonatal Fc receptor (FcRn) regulates IgG and albumin homeostasis, mediates
maternal IgG transport, takes an active role in phagocytosis, and delivers antigen for …
maternal IgG transport, takes an active role in phagocytosis, and delivers antigen for …
[HTML][HTML] Measuring peroxidasin activity in live cells using bromide addition for signal amplification
Peroxidasin (PXDN) is involved in the crosslinking of collagen IV, a major constituent of
basement membranes. Disruption of basement membrane integrity as observed in genetic …
basement membranes. Disruption of basement membrane integrity as observed in genetic …
FcRn overexpression in transgenic mice results in augmented APC activity and robust immune response with increased diversity of induced antibodies
A Végh, A Farkas, D Kövesdi, K Papp, J Cervenak… - PLoS …, 2012 - journals.plos.org
Our previous studies have shown that overexpression of bovine FcRn (bFcRn) in transgenic
(Tg) mice leads to an increase in the humoral immune response, characterized by larger …
(Tg) mice leads to an increase in the humoral immune response, characterized by larger …