Tumor microenvironment in prostate cancer: toward identification of novel molecular biomarkers for diagnosis, prognosis, and therapy development

HF Bahmad, M Jalloul, J Azar, MM Moubarak… - Frontiers in …, 2021 - frontiersin.org
Prostate cancer (PCa) is by far the most commonly diagnosed cancer in men worldwide.
Despite sensitivity to androgen deprivation, patients with advanced disease eventually …

Neuroendocrine differentiation of prostate cancer—An intriguing example of tumor evolution at play

GK Patel, N Chugh, M Tripathi - Cancers, 2019 - mdpi.com
Our understanding of neuroendocrine prostate cancer (NEPC) has assumed a new
perspective in light of the recent advances in research. Although classical NEPC is rarely …

RACK1 promotes cancer progression by increasing the M2/M1 macrophage ratio via the NF‐κB pathway in oral squamous cell carcinoma

H Dan, S Liu, J Liu, D Liu, F Yin, Z Wei… - Molecular …, 2020 - Wiley Online Library
Receptor for activated C kinase 1 (RACK1) has been shown to promote oral squamous cell
carcinoma (OSCC) progression, and RACK1 expression levels have been negatively …

[HTML][HTML] A modular master regulator landscape controls cancer transcriptional identity

EO Paull, A Aytes, SJ Jones, PS Subramaniam… - Cell, 2021 - cell.com
Despite considerable efforts, the mechanisms linking genomic alterations to the
transcriptional identity of cancer cells remain elusive. Integrative genomic analysis, using a …

Transcriptional mediators of treatment resistance in lethal prostate cancer

MX He, MS Cuoco, J Crowdis, A Bosma-Moody… - Nature medicine, 2021 - nature.com
Metastatic castration-resistant prostate cancer is typically lethal, exhibiting intrinsic or
acquired resistance to second-generation androgen-targeting therapies and minimal …

Osteoarthritis and toll-like receptors: when innate immunity meets chondrocyte apoptosis

G Barreto, M Manninen, K K. Eklund - Biology, 2020 - mdpi.com
Osteoarthritis (OA) has long been viewed as a degenerative disease of cartilage, but
accumulating evidence indicates that inflammation has a critical role in its pathogenesis. In …

[HTML][HTML] ELF3, ELF5, EHF and SPDEF transcription factors in tissue homeostasis and cancer

IY Luk, CM Reehorst, JM Mariadason - Molecules, 2018 - mdpi.com
The epithelium-specific ETS (ESE) transcription factors (ELF3, ELF5, EHF and SPDEF) are
defined by their highly conserved ETS DNA binding domain and predominant epithelial …

Epithelial-to-mesenchymal transition-related markers in prostate cancer: From bench to bedside

S Gogola, M Rejzer, HF Bahmad, W Abou-Kheir… - Cancers, 2023 - mdpi.com
Simple Summary Prostate cancer (PCa) is the second most frequent type of cancer in men
worldwide. Treatment options for early-stage PCa include external beam radiation therapy …

Roles of CCL2-CCR2 axis in the tumor microenvironment

S Kadomoto, K Izumi, A Mizokami - International Journal of Molecular …, 2021 - mdpi.com
Chemokines are a small family of cytokines that were first discovered as chemotactic factors
in leukocytes during inflammation, and reports on the relationship between chemokines and …

Cell plasticity and prostate cancer: The role of epithelial–mesenchymal transition in tumor progression, invasion, metastasis and cancer therapy resistance

S Papanikolaou, A Vourda, S Syggelos, K Gyftopoulos - Cancers, 2021 - mdpi.com
Simple Summary Although epithelial-to-mesenchymal transition (EMT) is a well-known
cellular process involved during normal embryogenesis and wound healing, it also has a …