Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer and a leading
cause of cancer-related deaths worldwide. Ninety percent of HCC cases arise from cirrhosis …

Aflatoxins are a class of carcinogenic mycotoxins produced by Aspergillus fungi and are
known to contaminate a large portion of the world's food supply. Aflatoxin B1 (AFB1) is the …

Unlike most tumor suppressor genes, the most common genetic alterations in tumor protein
p53 (TP53) are missense mutations,. Mutant p53 protein is often abundantly expressed in …

The p53 gene contains homozygous mutations in~ 50–60% of human cancers. About 90%
of these mutations encode missense mutant proteins that span~ 190 different codons …

Aflatoxins are a class of carcinogenic mycotoxins produced by Aspergillus fungi, which are
widely distributed in nature. Aflatoxin B1 (AFB1) is the most toxic of these compounds and its …

Hepatitis B virus (HBV) contributes to hepatocellular carcinoma (HCC) development through
direct and indirect mechanisms. HBV DNA integration into the host genome occurs at early …

ABSTRACT TP53 gene mutations are one of the most frequent somatic events in cancer.
The IARC TP53 Database (http://p53. iarc. fr) is a popular resource that compiles occurrence …

Hepatocellular carcinoma (HCC) has emerged as a major cause of cancer-related death. Its
mortality has increased in Western populations, with a minority of patients diagnosed at …

Explosive advances in next‐generation sequencer (NGS) and computational analyses have
enabled exploration of somatic protein‐altered mutations in most cancer types, with coding …

Genomic analyses promise to improve tumor characterization to optimize personalized
treatment for patients with hepatocellular carcinoma (HCC). Exome sequencing analysis of …