Myocardial ischemia is a disease with high morbidity and mortality, for which reperfusion is
currently the standard intervention. However, the reperfusion may lead to further myocardial …

Ischemia-reperfusion injury is associated with serious clinical manifestations, including
myocardial hibernation, acute heart failure, cerebral dysfunction, gastrointestinal …

Ischemia-reperfusion (IR) injury is central to the pathology of major cardiovascular diseases,
such as stroke and myocardial infarction. IR injury is mediated by several factors including …

Reperfusion injury, the paradoxical tissue response that is manifested by blood flow-
deprived and oxygen-starved organs following the restoration of blood flow and tissue …

Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon,
inevitable in kidney transplantation and one of the most important mechanisms for non-or …

The gasotransmitters are a family of gaseous signaling molecules which are produced
endogenously and act at specific receptors to play imperative roles in physiologic and …

The production of various reactive oxidant species in excess of endogenous antioxidant
defense mechanisms promotes the development of a state of oxidative stress, with …

Ischemia/reperfusion injury is an unavoidable relevant consequence after kidney
transplantation and influences short term as well as long-term graft outcome. Clinically …

The discovery of soluble GC (sGC) stimulators and sGC activators provided valuable tools to
elucidate NO–sGC signalling and opened novel pharmacological opportunities for …

Reduced nitric oxide bioavailability contributes to endothelial dysfunction and hypertension.
The endothelial isoform of nitric oxide synthase (eNOS) is responsible for the production of …